HitPredict

Interactor 1: RAD53 (P22216)
Serine/threonine-protein kinase RAD53 (EC 2.7.12.1) (CHEK2 homolog) (Serine-protein kinase 1)
Gene: RAD53

Interactor 2: SWI4 (P25302)
Regulatory protein SWI4 (Cell-cycle box factor subunit SWI4) (Protein ART1)
Gene: SWI4

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	11805837, 17130285, 37766847
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~Pkinase
Common GO terms	GO:0005634 - nucleus
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 821 Sc			1 1093
+	Sc
		456988 RAD53_YEAST (1-821): 0: 676: 100.00		SWI6_YEAST (339-886): 5.93e-61: 225: 18.79
+	Sc
		606013 RAD53_YEAST (1-821): 0: 676: 100.00		MBP1_YEAST (639-1092): 2.7e-12: 73.1: 16.20
+	Hs
		331347 CHK2_HUMAN (39-504): 6.09e-136: 416: 29.36		RAI14_HUMAN (456-1093): 1.81e-20: 100: 12.60
+	Hs
		229982 NUAK1_HUMAN (200-576): 1.7e-46: 178: 29.66		RAI14_HUMAN (456-1093): 1.81e-20: 100: 12.60
+	Rn
		506766 KCC2A_RAT (202-466): 1.92e-46: 174: 34.70		CSKI1_RAT (472-675): 9.34e-15: 81.5: 15.02