HitPredict

Interactor 1: RAD53 (P22216)
Serine/threonine-protein kinase RAD53 (EC 2.7.12.1) (CHEK2 homolog) (Serine-protein kinase 1)
Gene: RAD53

Interactor 2: CDC5 (P32562)
Cell cycle serine/threonine-protein kinase CDC5/MSD2 (EC 2.7.11.21)
Gene: CDC5

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.83 1.00 0.912

The method score is based on:

Property Details
Experiments 20126259, 20098491, 23564203, 20046099
Identification Methods anti bait coimmunoprecipitation, protein kinase assay, affinity chromatography technology, enzymatic study
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains FHA~Pkinase, Pkinase~Pkinase
Common GO terms GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
and 2 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 821
Sc

1 705
+ Hs
+ Hs
+ Hs
+ At
+ Gm
+ At
+ At
+ At
+ Hs
+ Hs
+ Hs
+ At
+ At
+ Ce
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024