HitPredict

Interactor 1: VPS15 (P22219)
Serine/threonine-protein kinase VPS15 (EC 2.7.11.1) (Golgi-retention defective mutant protein 8) (Vacuolar protein sorting-associated protein 15)
Gene: VPS15

Interactor 2: PP2C3 (P34221)
Protein phosphatase 2C homolog 3 (PP2C-3) (EC 3.1.3.16)
Gene: PTC3

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.80	0.717

Property	Details
Experiments	11805826, 16429126
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PP2C~Pkinase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1454 Sc			1 468
+	At
		829494 KIN10_ARATH (12-524): 5.56e-128: 408: 13.58		P2C56_ARATH (9-305): 8.53e-97: 300: 24.27
+	At
		138640 CIPKN_ARATH (1-462): 1.17e-124: 398: 15.07		P2C77_ARATH (9-305): 4.91e-95: 295: 24.64
+	At
		829524 CIPKO_ARATH (19-457): 2.83e-122: 391: 14.77		P2C56_ARATH (9-305): 8.53e-97: 300: 24.27
+	At
		1105365 KIN10_ARATH (12-524): 5.56e-128: 408: 13.58		P2C78_ARATH (22-254): 2.31e-89: 280: 31.08
+	At
		1274921 CIPKN_ARATH (1-462): 1.17e-124: 398: 15.07		P2C03_ARATH (10-300): 3.4e-93: 290: 25.43
+	At
		138649 CIPKO_ARATH (19-457): 2.83e-122: 391: 14.77		P2C77_ARATH (9-305): 4.91e-95: 295: 24.64
+	Hs
		682190 AKT2_HUMAN (2-364): 8.28e-118: 380: 14.75		PHLP2_HUMAN (8-465): 1.15e-90: 302: 18.20
+	At
		1337633 CIPKO_ARATH (19-457): 2.83e-122: 391: 14.77		P2C03_ARATH (10-300): 3.4e-93: 290: 25.43
+	At
		187499 CIPKB_ARATH (25-392): 1.18e-117: 378: 15.59		P2C56_ARATH (9-305): 8.53e-97: 300: 24.27
+	At
		829522 CIPKK_ARATH (24-443): 1.27e-117: 378: 14.65		P2C56_ARATH (9-305): 8.53e-97: 300: 24.27
+	At
		138655 CIPK8_ARATH (24-462): 9.6e-119: 381: 14.25		P2C77_ARATH (9-305): 4.91e-95: 295: 24.64
+	At
		1338944 CIPKG_ARATH (13-448): 5.95e-119: 382: 15.19		P2C03_ARATH (10-300): 3.4e-93: 290: 25.43
+	Hs
		681911 AKT1_HUMAN (2-364): 4.63e-113: 367: 15.51		PHLP2_HUMAN (8-465): 1.15e-90: 302: 18.20
+	Hs
		273369 MARK3_HUMAN (22-293): 7.76e-70: 252: 22.10		PPM1B_HUMAN (1-464): 1.28e-134: 398: 26.33
+	At
		138629 CDPKC_ARATH (18-391): 3.82e-104: 342: 17.78		P2C77_ARATH (9-305): 4.91e-95: 295: 24.64
+	Rn
		61799 MK03_RAT (92-241): 3.25e-09: 62.8: 30.46		A6H9I0_RAT (1-442): 2.15e-131: 389: 26.48
+	Rn
		594788 MK03_RAT (92-241): 3.25e-09: 62.8: 30.46		PPM1A_RAT (1-369): 1.33e-120: 359: 27.97
+	Rn
		1144326 KCC1A_RAT (83-292): 2.27e-10: 66.2: 27.32		PPM1E_RAT (25-440): 4.37e-111: 346: 23.58
+	Rn
		926516 MK01_RAT (92-241): 7.87e-09: 61.2: 30.46		PPM1E_RAT (25-440): 4.37e-111: 346: 23.58
+	Hs
		176122 MARK3_HUMAN (22-293): 7.76e-70: 252: 22.10		PPM1G_HUMAN (24-115): 9.52e-16: 81.6: 43.48