HitPredict

Interactor 1: VPS15 (P22219)
Serine/threonine-protein kinase VPS15 (EC 2.7.11.1) (Golgi-retention defective mutant protein 8) (Vacuolar protein sorting-associated protein 15)
Gene: VPS15

Interactor 2: YPT52 (P36018)
GTP-binding protein YPT52
Gene: YPT52

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	23904270
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0000329 - fungal-type vacuole membrane GO:0005770 - late endosome GO:0006623 - protein targeting to vacuole
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1454 Sc			1 234
+	Sc
		606255 VPS15_YEAST (1-1454): 0: 1347: 100.00		VPS21_YEAST (5-232): 5.97e-57: 181: 48.25
+	Hs
		592453 PI3R4_HUMAN (1-1454): 0: 1054: 24.57		RAB5A_HUMAN (3-234): 3.63e-56: 179: 46.35
+	Dm
		1358722 Q9VHH2_DROME (1-1454): 0: 1026: 22.46		RAB5_DROME (3-233): 1.83e-59: 188: 50.22
+	At
		1107296 M3KE1_ARATH (12-1049): 4.91e-136: 455: 10.68		RAA1B_ARATH (4-234): 4.33e-73: 222: 31.60
+	At
		221736 KIN10_ARATH (12-524): 5.56e-128: 408: 13.58		RAA1E_ARATH (4-234): 8.81e-74: 224: 31.90
+	Hs
		844585 MARK2_HUMAN (2-580): 3.58e-118: 391: 13.89		RAB5C_HUMAN (3-234): 1.58e-79: 239: 46.55
+	Hs
		914159 MARK2_HUMAN (2-580): 3.58e-118: 391: 13.89		RB11A_HUMAN (4-233): 2.3e-73: 223: 33.33
+	Hs
		592336 MARK2_HUMAN (2-580): 3.58e-118: 391: 13.89		RAB5A_HUMAN (3-234): 3.63e-56: 179: 46.35
+	Zm
		8047 A0A1D6EK73_MAIZE (19-524): 3.54e-123: 395: 13.70		B4F7V6_MAIZE (5-234): 3.55e-52: 169: 46.12
+	Hs
		647864 MARK3_HUMAN (22-293): 7.76e-70: 252: 22.10		RB11A_HUMAN (4-233): 2.3e-73: 223: 33.33
+	Hs
		592109 MARK3_HUMAN (22-293): 7.76e-70: 252: 22.10		RAB5A_HUMAN (3-234): 3.63e-56: 179: 46.35