Interactor 1: GCH1 (P22288)
GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I)
Gene: GCH1

Interactor 2: GFRP (P70552)
GTP cyclohydrolase 1 feedback regulatory protein (GFRP) (GTP cyclohydrolase I feedback regulatory protein) (p35)
Gene: Gchfr

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.888

The method score is based on:

Property Details
Experiments 9685352, 9092499, 11818540, 15448133
Identification Methods enzymatic study, x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains GFRP~GTP_cyclohydroI
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0030742 - GTP-dependent protein binding
GO:0031965 - nuclear membrane
and 3 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 241
Rn

1 84
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024