HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UBE2A (P49459)
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)
Gene: UBE2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.942

Property	Details
Experiments	25527291, 27425610, 31887036, 36563856, 22427669, 17597759
Identification Methods	enzymatic study, pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1058 Hs			1 152
+	Hs
		607190 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D4_HUMAN (5-149): 1.13e-78: 231: 40.69
+	Hs
		607026 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D1_HUMAN (5-149): 5.04e-78: 229: 40.00
+	Hs
		607050 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62
+	Hs
		607039 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2D3_HUMAN (5-149): 1.9e-76: 225: 38.62
+	Hs
		607054 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UBE2B_HUMAN (1-151): 3.28e-74: 219: 96.03
+	Hs
		607136 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E2_HUMAN (3-150): 6.19e-73: 218: 35.14
+	Hs
		607129 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E3_HUMAN (3-150): 2.3e-72: 217: 35.14
+	Hs
		607028 UBA1_HUMAN (1-1058): 0: 1358: 100.00		UB2E1_HUMAN (3-150): 5.05e-71: 213: 36.49
+	Sp
		293848 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC4_SCHPO (5-149): 1.27e-76: 226: 38.62
+	Sc
		549788 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC4_YEAST (1-149): 1.43e-77: 228: 36.91
+	Sp
		293847 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC2_SCHPO (1-150): 2.83e-70: 209: 72.00
+	Sc
		410211 UBA1_YEAST (38-1057): 0: 1063: 51.50		UBC2_YEAST (1-150): 2.29e-73: 218: 69.33
+	Hs
		48104 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D1_HUMAN (5-149): 5.04e-78: 229: 40.00
+	Hs
		48107 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62
+	Hs
		48106 UBA6_HUMAN (12-1057): 0: 1037: 41.09		UB2D3_HUMAN (5-149): 1.9e-76: 225: 38.62
+	Hs
		782203 UBA7_HUMAN (41-1057): 0: 1006: 46.00		UB2E1_HUMAN (3-150): 5.05e-71: 213: 36.49
+	Sp
		116506 UBA1_SCHPO (36-1053): 0: 1080: 53.37		UBC7_SCHPO (5-148): 1.48e-37: 127: 39.87
+	Hs
		1282360 SAE2_HUMAN (60-451): 2.55e-88: 299: 17.08		UB2E3_HUMAN (3-150): 2.3e-72: 217: 35.14
+	Hs
		919796 UBA3_HUMAN (847-1018): 1.74e-12: 72.9: 17.13		UB2D2_HUMAN (5-149): 7.73e-78: 229: 38.62