HitPredict

Interactor 1: UBA1 (P22314)
Ubiquitin-like modifier-activating enzyme 1 (EC 6.2.1.45) (Protein A1S9) (Ubiquitin-activating enzyme E1)
Gene: UBA1

Interactor 2: UBE2N (P61088)
Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Gene: UBE2N

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 14517261, 25527291, 27173435, 29537486, 30097011, 27182664, 31638574, 33619271, 35271311, 35355521, 36563856, 18678647, 18570872, 19734906
Identification Methods enzymatic study, affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, ubiquitination reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms GO:0003723 - RNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024