HitPredict

Interactor 1: HNF1A (P22361)
Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
Gene: HNF1A

Interactor 2: PHS (P61458)
Pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Dimerization cofactor of hepatocyte nuclear factor 1-alpha) (DCoH) (Dimerization cofactor of HNF1) (Phenylalanine hydroxylase-stimulating protein) (Pterin carbinolamine dehydratase) (PCD)
Gene: Pcbd1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	20211142, 15182178
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 628 Mm			1 104
+	Mm
		607525 HNF1A_MOUSE (1-628): 0: 686: 100.00		PHS2_MOUSE (1-103): 7.64e-49: 153: 65.05
+	Hs
		595917 HNF1A_HUMAN (1-628): 0: 654: 94.61		PHS_HUMAN (1-104): 6.3e-50: 154: 99.04
+	Hs
		595955 HNF1A_HUMAN (1-628): 0: 654: 94.61		PHS2_HUMAN (1-103): 1.58e-46: 147: 60.19
+	Hs
		727496 HNF1B_HUMAN (1-539): 4.55e-153: 454: 53.21		PHS_HUMAN (1-104): 6.3e-50: 154: 99.04
+	Mm
		655008 HNF1B_MOUSE (1-539): 8.85e-150: 446: 53.29		PHS_MOUSE (1-104): 3.02e-50: 155: 100.00
+	Hs
		727585 HNF1B_HUMAN (1-539): 4.55e-153: 454: 53.21		PHS2_HUMAN (1-103): 1.58e-46: 147: 60.19