HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	28205554, 35384245
Identification Methods	fluorescent resonance energy transfer, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	I-set~fn3, Ig_3~fn3, EphA2_TM~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0043235 - receptor complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 976
+	Hs
		601465 FGFR2_HUMAN (4-797): 0: 737: 56.44		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		607974 FGFR4_HUMAN (13-802): 0: 750: 100.00		EPHA7_HUMAN (4-974): 0: 1128: 50.30
+	Hs
		607929 FGFR4_HUMAN (13-802): 0: 750: 100.00		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		601484 FGFR2_HUMAN (4-797): 0: 737: 56.44		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		609184 FGFR3_HUMAN (5-799): 0: 712: 61.07		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		507871 FGFR1_HUMAN (3-794): 0: 706: 54.76		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		609225 FGFR3_HUMAN (5-799): 0: 712: 61.07		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		507926 FGFR1_HUMAN (3-794): 0: 706: 54.76		EPHA4_HUMAN (1-976): 0: 1121: 50.25
+	Hs
		665142 EPHA3_HUMAN (4-778): 0: 595: 18.34		EPHA2_HUMAN (1-976): 0: 1141: 100.00
+	Hs
		665383 EPHA3_HUMAN (4-778): 0: 595: 18.34		EPHA5_HUMAN (11-976): 0: 1127: 51.34
+	Hs
		665374 EPHA3_HUMAN (4-778): 0: 595: 18.34		EPHB2_HUMAN (28-973): 0: 1089: 48.29
+	Hs
		665384 EPHA3_HUMAN (4-778): 0: 595: 18.34		EPHB4_HUMAN (14-970): 0: 986: 44.99
+	Hs
		435536 FGFR4_HUMAN (13-802): 0: 750: 100.00		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		601456 FGFR2_HUMAN (4-797): 0: 737: 56.44		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		435514 FGFR1_HUMAN (3-794): 0: 706: 54.76		IGF1R_HUMAN (393-877): 8.17e-134: 437: 30.00
+	Hs
		609173 FGFR3_HUMAN (5-799): 0: 712: 61.07		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		507857 FGFR1_HUMAN (3-794): 0: 706: 54.76		FGFR3_HUMAN (381-889): 9.01e-137: 431: 24.65
+	Hs
		433576 FGFR4_HUMAN (13-802): 0: 750: 100.00		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		433573 FGFR2_HUMAN (4-797): 0: 737: 56.44		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91
+	Hs
		433602 EPHA3_HUMAN (4-778): 0: 595: 18.34		LYN_HUMAN (607-879): 2.06e-64: 228: 42.91