HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: MERL (P35240)
Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)
Gene: NF2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	28205554, 35384245
Identification Methods	fluorescent resonance energy transfer, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	FERM_M~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 595
+	Hs
		507884 FGFR1_HUMAN (3-794): 0: 706: 54.76		MERL_HUMAN (1-595): 1.12e-172: 504: 100.00
+	Hs
		546928 FGFR4_HUMAN (13-802): 0: 750: 100.00		EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20
+	Hs
		607901 FGFR4_HUMAN (13-802): 0: 750: 100.00		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		607883 FGFR4_HUMAN (13-802): 0: 750: 100.00		MOES_HUMAN (19-595): 5.97e-146: 435: 44.44
+	Hs
		609192 FGFR3_HUMAN (5-799): 0: 712: 61.07		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		507828 FGFR1_HUMAN (3-794): 0: 706: 54.76		EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20
+	Hs
		507885 FGFR1_HUMAN (3-794): 0: 706: 54.76		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		507865 FGFR1_HUMAN (3-794): 0: 706: 54.76		MOES_HUMAN (19-595): 5.97e-146: 435: 44.44
+	Hs
		505551 FGFR3_HUMAN (5-799): 0: 712: 61.07		EPB41_HUMAN (3-566): 9.71e-126: 392: 19.73
+	Hs
		508209 FGFR1_HUMAN (3-794): 0: 706: 54.76		E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46
+	Hs
		665158 EPHA2_HUMAN (4-789): 0: 573: 19.58		MERL_HUMAN (1-595): 1.12e-172: 504: 100.00
+	Hs
		299238 FGFR3_HUMAN (5-799): 0: 712: 61.07		FARP2_HUMAN (3-537): 6.42e-112: 360: 17.89
+	Hs
		508287 FGFR1_HUMAN (3-794): 0: 706: 54.76		FARP1_HUMAN (2-526): 5.38e-114: 366: 18.35
+	Hs
		665554 EPHB2_HUMAN (4-779): 0: 557: 17.27		MERL_HUMAN (1-595): 1.12e-172: 504: 100.00
+	Hs
		719689 EPHA5_HUMAN (4-771): 0: 580: 18.81		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		546943 EPHA2_HUMAN (4-789): 0: 573: 19.58		EZRI_HUMAN (19-595): 8.21e-152: 450: 44.20
+	Hs
		665555 EPHB2_HUMAN (4-779): 0: 557: 17.27		RADI_HUMAN (19-595): 5.41e-151: 448: 45.47
+	Hs
		640048 EPHB2_HUMAN (4-779): 0: 557: 17.27		MOES_HUMAN (19-595): 5.97e-146: 435: 44.44
+	Hs
		665337 EPHA2_HUMAN (4-789): 0: 573: 19.58		E41LA_HUMAN (19-416): 3.96e-121: 375: 24.46
+	Mm
		546328 NTRK2_MOUSE (122-757): 5e-166: 503: 26.62		E41L3_MOUSE (14-544): 5.06e-116: 368: 20.89