HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: KLOTB (Q86Z14)
Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)
Gene: KLB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17623664
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Glyco_hydro_1~I-set
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0017134 - fibroblast growth factor binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 802 Hs			1 1044
+	Hs
		601541 FGFR2_HUMAN (4-797): 0: 737: 56.44		KLOTB_HUMAN (1-1044): 0: 1400: 100.00
+	Hs
		609401 FGFR3_HUMAN (5-799): 0: 712: 61.07		KLOTB_HUMAN (1-1044): 0: 1400: 100.00
+	Hs
		508088 FGFR1_HUMAN (3-794): 0: 706: 54.76		KLOTB_HUMAN (1-1044): 0: 1400: 100.00
+	Mm
		975159 FGFR4_MOUSE (1-802): 0: 741: 89.78		KLOTB_MOUSE (1-1044): 0: 1356: 78.76
+	Mm
		555271 FGFR1_MOUSE (3-794): 0: 703: 54.88		KLOTB_MOUSE (1-1044): 0: 1356: 78.76
+	Mm
		192163 FGFR4_MOUSE (1-802): 0: 741: 89.78		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Mm
		192159 FGFR2_MOUSE (4-797): 0: 712: 56.31		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Mm
		192157 FGFR1_MOUSE (3-794): 0: 703: 54.88		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Mm
		192164 FGFR3_MOUSE (6-785): 0: 703: 60.33		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Mm
		93854 E9QNJ9_MOUSE (6-785): 0: 684: 58.61		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Ce
		1014307 EGL15_CAEEL (17-245): 2.84e-25: 114: 16.73		Q18758_CAEEL (521-963): 3.03e-156: 473: 24.44