HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: KS6A6 (Q9UK32)
Ribosomal protein S6 kinase alpha-6 (S6K-alpha-6) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 6) (p90-RSK 6) (p90RSK6) (Ribosomal S6 kinase 4) (RSK-4) (pp90RSK4)
Gene: RPS6KA6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 802 Hs			1 745
+	Hs
		607926 FGFR4_HUMAN (13-802): 0: 750: 100.00		KS6A3_HUMAN (2-745): 0: 806: 76.54
+	Hs
		601482 FGFR2_HUMAN (4-797): 0: 737: 56.44		KS6A3_HUMAN (2-745): 0: 806: 76.54
+	Hs
		607975 FGFR4_HUMAN (13-802): 0: 750: 100.00		KS6A1_HUMAN (2-743): 0: 786: 71.54
+	Hs
		601517 FGFR2_HUMAN (4-797): 0: 737: 56.44		KS6A1_HUMAN (2-743): 0: 786: 71.54
+	Hs
		609219 FGFR3_HUMAN (5-799): 0: 712: 61.07		KS6A3_HUMAN (2-745): 0: 806: 76.54
+	Hs
		507919 FGFR1_HUMAN (3-794): 0: 706: 54.76		KS6A3_HUMAN (2-745): 0: 806: 76.54
+	Hs
		508016 FGFR1_HUMAN (3-794): 0: 706: 54.76		KS6A1_HUMAN (2-743): 0: 786: 71.54
+	Rn
		979772 FGFR1_RAT (3-794): 0: 698: 54.27		KS6A1_RAT (2-743): 0: 787: 72.02
+	Hs
		384525 NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53		KS6A3_HUMAN (2-745): 0: 806: 76.54
+	Hs
		384892 NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53		KS6A1_HUMAN (2-743): 0: 786: 71.54
+	Hs
		434163 RET_HUMAN (221-802): 2.33e-148: 465: 34.72		KS6A3_HUMAN (2-745): 0: 806: 76.54
+	Hs
		607895 FGFR4_HUMAN (13-802): 0: 750: 100.00		AKT1_HUMAN (417-742): 1.91e-117: 363: 24.13
+	Hs
		507876 FGFR1_HUMAN (3-794): 0: 706: 54.76		AKT1_HUMAN (417-742): 1.91e-117: 363: 24.13
+	Hs
		601516 FGFR2_HUMAN (4-797): 0: 737: 56.44		KS6A2_HUMAN (2-330): 1.75e-100: 327: 23.46
+	Hs
		508015 FGFR1_HUMAN (3-794): 0: 706: 54.76		KS6A2_HUMAN (2-330): 1.75e-100: 327: 23.46
+	Hs
		665151 EPHA2_HUMAN (4-789): 0: 573: 19.58		AKT1_HUMAN (417-742): 1.91e-117: 363: 24.13
+	Hs
		665243 EPHA2_HUMAN (4-789): 0: 573: 19.58		KS6A2_HUMAN (2-330): 1.75e-100: 327: 23.46