HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: TNIK (Q9UKE5)
TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0046777 - protein autophosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 1360
+	Hs
		508260 FGFR1_HUMAN (3-794): 0: 706: 54.76		TNIK_HUMAN (1-1360): 0: 1235: 100.00
+	Hs
		1072625 EPHA7_HUMAN (4-781): 0: 584: 19.90		TNIK_HUMAN (1-1360): 0: 1235: 100.00
+	Hs
		508100 FGFR1_HUMAN (3-794): 0: 706: 54.76		MINK1_HUMAN (1-1360): 0: 1051: 60.43
+	Hs
		324739 FGFR4_HUMAN (13-802): 0: 750: 100.00		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		324728 FGFR1_HUMAN (3-794): 0: 706: 54.76		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		1072547 EPHA7_HUMAN (4-781): 0: 584: 19.90		MINK1_HUMAN (1-1360): 0: 1051: 60.43
+	Hs
		324809 EPHA7_HUMAN (4-781): 0: 584: 19.90		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		601516 FGFR2_HUMAN (4-797): 0: 737: 56.44		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Hs
		607926 FGFR4_HUMAN (13-802): 0: 750: 100.00		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		601482 FGFR2_HUMAN (4-797): 0: 737: 56.44		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		608180 FGFR4_HUMAN (13-802): 0: 750: 100.00		KS6A6_HUMAN (10-709): 1.13e-130: 422: 16.27
+	Hs
		508015 FGFR1_HUMAN (3-794): 0: 706: 54.76		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Hs
		609219 FGFR3_HUMAN (5-799): 0: 712: 61.07		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		507919 FGFR1_HUMAN (3-794): 0: 706: 54.76		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		507867 FGFR1_HUMAN (3-794): 0: 706: 54.76		MARK3_HUMAN (3-675): 1.72e-124: 406: 16.37
+	Hs
		607975 FGFR4_HUMAN (13-802): 0: 750: 100.00		KS6A1_HUMAN (2-350): 9.65e-97: 329: 22.63
+	Hs
		601517 FGFR2_HUMAN (4-797): 0: 737: 56.44		KS6A1_HUMAN (2-350): 9.65e-97: 329: 22.63
+	Hs
		508016 FGFR1_HUMAN (3-794): 0: 706: 54.76		KS6A1_HUMAN (2-350): 9.65e-97: 329: 22.63
+	Rn
		979772 FGFR1_RAT (3-794): 0: 698: 54.27		KS6A1_RAT (1-350): 3.49e-98: 333: 22.95
+	Hs
		508290 FGFR1_HUMAN (3-794): 0: 706: 54.76		M4K5_HUMAN (19-373): 7.89e-73: 263: 40.38