HitPredict

Interactor 1: KCNA4 (P22459)
Potassium voltage-gated channel subfamily A member 4 (HPCN2) (Voltage-gated K(+) channel HuKII) (Voltage-gated potassium channel HBK4) (Voltage-gated potassium channel HK1) (Voltage-gated potassium channel subunit Kv1.4)
Gene: KCNA4

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.757

Property	Details
Experiments	12435606, 11744724, 11723117, 11997254, 9581762, 8938729, 8601796, 7477295, 11937501
Identification Methods	two hybrid, pull down, affinity chromatography technology, far western blotting, fluorescence polarization spectroscopy, enzyme linked immunosorbent assay
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043197 - dendritic spine
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 653 Hs			1 724
+	Rn
		548174 KCNA4_RAT (1-653): 0: 587: 96.03		DLG4_RAT (1-724): 0: 668: 99.86
+	Mm
		1142574 KCNA4_MOUSE (1-653): 0: 576: 96.79		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		602901 KCNA3_HUMAN (84-653): 3.65e-154: 459: 60.07		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Hs
		608268 KCNA5_HUMAN (50-636): 1.02e-149: 448: 54.82		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		927733 KCNA2_MOUSE (140-653): 1.88e-150: 446: 65.95		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		942333 KCNA1_HUMAN (140-653): 2.24e-150: 446: 65.56		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Hs
		558713 KCNA2_HUMAN (140-653): 4.02e-150: 445: 65.76		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		558703 KCNA1_MOUSE (140-653): 8.02e-150: 444: 65.56		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		608230 KCNA4_HUMAN (1-653): 0: 595: 100.00		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		608222 KCNA4_HUMAN (1-653): 0: 595: 100.00		EM55_HUMAN (2-325): 2.03e-22: 103: 14.41
+	Hs
		608224 KCNA4_HUMAN (1-653): 0: 595: 100.00		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		608232 KCNA4_HUMAN (1-653): 0: 595: 100.00		MPP7_HUMAN (8-289): 1.03e-19: 95.5: 12.50
+	Hs
		159156 KCNA4_HUMAN (1-653): 0: 595: 100.00		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29
+	Hs
		608231 KCNA4_HUMAN (1-653): 0: 595: 100.00		DLG2_HUMAN (225-474): 2.32e-18: 92.1: 21.09
+	Hs
		608244 KCNA4_HUMAN (1-653): 0: 595: 100.00		DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58
+	Rn
		548175 KCNA4_RAT (1-653): 0: 587: 96.03		DLG3_RAT (221-548): 5.99e-15: 80.9: 18.55
+	Rn
		580271 KCNA5_RAT (44-636): 7.42e-156: 464: 55.28		DLG1_RAT (143-465): 5.52e-20: 97.1: 20.97
+	Hs
		608277 KCNA5_HUMAN (50-636): 1.02e-149: 448: 54.82		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		602905 KCNA3_HUMAN (84-653): 3.65e-154: 459: 60.07		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		608272 KCNA5_HUMAN (50-636): 1.02e-149: 448: 54.82		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93