HitPredict

Interactor 1: KCNA4 (P22459)
Potassium voltage-gated channel subfamily A member 4 (HPCN2) (Voltage-gated K(+) channel HuKII) (Voltage-gated potassium channel HBK4) (Voltage-gated potassium channel HK1) (Voltage-gated potassium channel subunit Kv1.4)
Gene: KCNA4

Interactor 2: LNX1 (Q8TBB1)
E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)
Gene: LNX1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.50	0.554

Property	Details
Experiments	22087225, 22889411
Identification Methods	affinity chromatography technology, two hybrid, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 653 Hs			1 728
+	Hs
		608224 KCNA4_HUMAN (1-653): 0: 595: 100.00		DLG1_HUMAN (354-728): 3.16e-29: 126: 16.15
+	Hs
		608221 KCNA4_HUMAN (1-653): 0: 595: 100.00		DLG4_HUMAN (581-725): 3.01e-21: 100: 22.22
+	Rn
		548174 KCNA4_RAT (1-653): 0: 587: 96.03		DLG4_RAT (267-582): 6.83e-21: 99.8: 16.09
+	Hs
		608230 KCNA4_HUMAN (1-653): 0: 595: 100.00		SCRIB_HUMAN (265-624): 2.64e-15: 82.4: 13.52
+	Mm
		1142574 KCNA4_MOUSE (1-653): 0: 576: 96.79		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40
+	Hs
		608244 KCNA4_HUMAN (1-653): 0: 595: 100.00		DLG3_HUMAN (619-713): 1.3e-14: 79.7: 28.87
+	Rn
		548175 KCNA4_RAT (1-653): 0: 587: 96.03		DLG3_RAT (523-713): 8.18e-16: 83.6: 17.62
+	Hs
		608231 KCNA4_HUMAN (1-653): 0: 595: 100.00		DLG2_HUMAN (352-500): 3.87e-11: 68.6: 18.59
+	Rn
		580271 KCNA5_RAT (44-636): 7.42e-156: 464: 55.28		DLG1_RAT (438-728): 1.75e-34: 143: 19.66
+	Hs
		602905 KCNA3_HUMAN (84-653): 3.65e-154: 459: 60.07		DLG1_HUMAN (354-728): 3.16e-29: 126: 16.15
+	Hs
		608272 KCNA5_HUMAN (50-636): 1.02e-149: 448: 54.82		DLG1_HUMAN (354-728): 3.16e-29: 126: 16.15
+	Mm
		558896 KCNA3_MOUSE (151-653): 1.09e-147: 440: 66.40		SCRIB_MOUSE (370-722): 3.86e-28: 123: 17.08
+	Hs
		602901 KCNA3_HUMAN (84-653): 3.65e-154: 459: 60.07		DLG4_HUMAN (581-725): 3.01e-21: 100: 22.22
+	Hs
		608268 KCNA5_HUMAN (50-636): 1.02e-149: 448: 54.82		DLG4_HUMAN (581-725): 3.01e-21: 100: 22.22
+	Mm
		927733 KCNA2_MOUSE (140-653): 1.88e-150: 446: 65.95		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40
+	Hs
		942333 KCNA1_HUMAN (140-653): 2.24e-150: 446: 65.56		DLG4_HUMAN (581-725): 3.01e-21: 100: 22.22
+	Hs
		558713 KCNA2_HUMAN (140-653): 4.02e-150: 445: 65.76		DLG4_HUMAN (581-725): 3.01e-21: 100: 22.22
+	Mm
		558703 KCNA1_MOUSE (140-653): 8.02e-150: 444: 65.56		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40
+	Mm
		558878 KCNA3_MOUSE (151-653): 1.09e-147: 440: 66.40		DLG4_MOUSE (267-582): 4.16e-21: 100: 16.40
+	Hs
		608277 KCNA5_HUMAN (50-636): 1.02e-149: 448: 54.82		SCRIB_HUMAN (265-624): 2.64e-15: 82.4: 13.52