HitPredict

Interactor 1: KCNA5 (P22460)
Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5)
Gene: KCNA5

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.669

Property	Details
Experiments	12860415, 12435606, 16466689
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0097110 - scaffold protein binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 613 Hs			1 724
+	Hs
		602901 KCNA3_HUMAN (37-599): 1.88e-169: 496: 58.39		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		927733 KCNA2_MOUSE (94-593): 8.64e-155: 456: 65.87		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		558713 KCNA2_HUMAN (90-593): 2.73e-154: 455: 64.43		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Mm
		558878 KCNA3_MOUSE (70-599): 1.94e-153: 453: 61.19		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		608221 KCNA4_HUMAN (93-599): 6.38e-150: 449: 61.24		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Hs
		942333 KCNA1_HUMAN (94-609): 2.41e-151: 447: 62.02		DLG4_HUMAN (1-724): 0: 667: 100.00
+	Rn
		548174 KCNA4_RAT (116-599): 5.84e-148: 444: 64.27		DLG4_RAT (1-724): 0: 668: 99.86
+	Mm
		558703 KCNA1_MOUSE (94-609): 7.98e-150: 443: 62.02		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		608277 KCNA5_HUMAN (1-613): 0: 604: 100.00		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		608272 KCNA5_HUMAN (1-613): 0: 604: 100.00		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Rn
		580271 KCNA5_RAT (1-613): 0: 602: 83.90		DLG1_RAT (143-465): 5.52e-20: 97.1: 20.97
+	Hs
		602905 KCNA3_HUMAN (37-599): 1.88e-169: 496: 58.39		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		608230 KCNA4_HUMAN (93-599): 6.38e-150: 449: 61.24		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		608222 KCNA4_HUMAN (93-599): 6.38e-150: 449: 61.24		EM55_HUMAN (2-325): 2.03e-22: 103: 14.41
+	Hs
		608224 KCNA4_HUMAN (93-599): 6.38e-150: 449: 61.24		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		608232 KCNA4_HUMAN (93-599): 6.38e-150: 449: 61.24		MPP7_HUMAN (8-289): 1.03e-19: 95.5: 12.50
+	Hs
		159156 KCNA4_HUMAN (93-599): 6.38e-150: 449: 61.24		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29
+	Hs
		608231 KCNA4_HUMAN (93-599): 6.38e-150: 449: 61.24		DLG2_HUMAN (225-474): 2.32e-18: 92.1: 21.09
+	Hs
		608244 KCNA4_HUMAN (93-599): 6.38e-150: 449: 61.24		DLG3_HUMAN (200-548): 1.7e-14: 79.4: 17.58
+	Rn
		548175 KCNA4_RAT (116-599): 5.84e-148: 444: 64.27		DLG3_RAT (221-548): 5.99e-15: 80.9: 18.55