HitPredict

Interactor 1: KCNA5 (P22460)
Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5)
Gene: KCNA5

Interactor 2: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	14506255
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 613 Hs			1 1038
+	Hs
		522777 KCNA5_HUMAN (1-613): 0: 604: 100.00		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		412012 KCNA5_HUMAN (1-613): 0: 604: 100.00		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		412009 KCNA3_HUMAN (37-599): 1.88e-169: 496: 58.39		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		411988 KCNA2_HUMAN (90-593): 2.73e-154: 455: 64.43		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		522776 KCNA4_HUMAN (93-599): 6.38e-150: 449: 61.24		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		412011 KCNA4_HUMAN (93-599): 6.38e-150: 449: 61.24		FYN_HUMAN (1-400): 2.52e-126: 397: 30.18
+	Hs
		558725 KCNA2_HUMAN (90-593): 2.73e-154: 455: 64.43		FAK2_HUMAN (49-624): 1.48e-117: 387: 26.22
+	Mm
		710133 KCNB1_MOUSE (90-577): 1.26e-127: 398: 29.79		FAK1_MOUSE (6-692): 1.85e-131: 426: 21.28
+	Hs
		983615 KCNB1_HUMAN (90-577): 7.42e-128: 398: 29.59		FAK1_HUMAN (6-692): 3.3e-131: 425: 21.01
+	Hs
		522988 KCNB1_HUMAN (90-577): 7.42e-128: 398: 29.59		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		523193 KCND3_HUMAN (85-613): 2.76e-127: 391: 29.60		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Hs
		433932 KCNB2_HUMAN (87-565): 8.66e-127: 397: 30.71		LYN_HUMAN (92-388): 4.52e-112: 358: 36.79