HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 724
+	Hs
		655220 EPHA3_HUMAN (1-786): 0: 641: 20.68		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		655380 EPHA7_HUMAN (1-782): 0: 626: 21.22		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		655222 EPHB2_HUMAN (1-788): 0: 624: 19.15		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		655284 EPHA5_HUMAN (1-777): 0: 622: 20.18		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		655285 EPHA4_HUMAN (1-781): 0: 622: 20.78		P85A_HUMAN (1-724): 0: 596: 100.00
+	Hs
		129209 EPHA3_HUMAN (1-786): 0: 641: 20.68		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129297 EPHA7_HUMAN (1-782): 0: 626: 21.22		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129211 EPHB2_HUMAN (1-788): 0: 624: 19.15		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129252 EPHA5_HUMAN (1-777): 0: 622: 20.18		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		129253 EPHA4_HUMAN (1-781): 0: 622: 20.78		P85B_HUMAN (4-719): 6.38e-162: 486: 57.24
+	Hs
		872468 EPHA5_HUMAN (1-777): 0: 622: 20.18		P55G_HUMAN (271-723): 1.4e-104: 329: 72.31
+	Hs
		64660 EPHB2_HUMAN (1-788): 0: 624: 19.15		RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99
+	Hs
		253355 EPHA7_HUMAN (1-782): 0: 626: 21.22		SRGP2_HUMAN (118-668): 3.41e-54: 203: 13.78
+	Hs
		253317 EPHB2_HUMAN (1-788): 0: 624: 19.15		SRGP2_HUMAN (118-668): 3.41e-54: 203: 13.78
+	Hs
		64749 EPHA6_HUMAN (1-774): 0: 600: 20.05		RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99
+	Hs
		64659 EPHA2_HUMAN (1-788): 0: 595: 21.50		RHG32_HUMAN (14-613): 1.13e-61: 227: 13.99
+	Mm
		975149 EPHA4_MOUSE (1-781): 0: 626: 20.78		CHIN_MOUSE (87-300): 4.48e-54: 194: 21.10
+	Rn
		88844 D3ZZK3_RAT (1-781): 0: 624: 20.66		CHIN_RAT (87-296): 8.17e-54: 190: 21.96
+	Mm
		763386 EPHA4_MOUSE (1-781): 0: 626: 20.78		FYN_MOUSE (573-724): 9.83e-33: 135: 22.50
+	Hs
		433265 EPHB2_HUMAN (1-788): 0: 624: 19.15		YES_HUMAN (568-724): 2.15e-31: 131: 20.61