HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: FGF9 (P31371)
Fibroblast growth factor 9 (FGF-9) (Glia-activating factor) (GAF) (Heparin-binding growth factor 9) (HBGF-9)
Gene: FGF9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.865

Property	Details
Experiments	8576175, 10574949, 14613973
Identification Methods	pull down, affinity chromatography technology, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	FGF~I-set, FGF~Ig_3
Common GO terms	GO:0002062 - chondrocyte differentiation GO:0005576 - extracellular region GO:0007267 - cell-cell signaling GO:0008284 - positive regulation of cell population proliferation GO:0008543 - fibroblast growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 208
+	Mm
		867550 FGFR3_MOUSE (1-806): 0: 793: 92.32		FGF9_MOUSE (1-208): 2.53e-108: 310: 99.52
+	Hs
		601113 FGFR3_HUMAN (10-806): 0: 819: 100.00		FGF7_HUMAN (47-193): 1.06e-65: 202: 38.51
+	Hs
		447022 FGFR3_HUMAN (10-806): 0: 819: 100.00		FGF2_HUMAN (12-190): 2.92e-55: 179: 32.78
+	Hs
		517733 FGFR3_HUMAN (10-806): 0: 819: 100.00		FGF5_HUMAN (62-201): 9.52e-54: 174: 44.44
+	Hs
		399134 FGFR3_HUMAN (10-806): 0: 819: 100.00		FGF1_HUMAN (58-195): 8.47e-55: 173: 38.85
+	Hs
		441809 FGFR3_HUMAN (10-806): 0: 819: 100.00		FGF4_HUMAN (28-191): 1.26e-53: 172: 38.55
+	Hs
		609227 FGFR3_HUMAN (10-806): 0: 819: 100.00		FGF8_HUMAN (26-192): 8.53e-44: 147: 31.46
+	Mm
		740709 FGFR3_MOUSE (1-806): 0: 793: 92.32		FGF8_MOUSE (22-192): 5.18e-43: 147: 28.74
+	Mm
		93855 E9QNJ9_MOUSE (1-806): 0: 764: 88.26		FGF23_MOUSE (18-206): 1.65e-44: 150: 23.74
+	Rn
		896711 Q63237_RAT (7-413): 2.16e-139: 421: 52.98		FGF1_RAT (57-195): 9.99e-56: 175: 39.29
+	Mm
		555263 FGFR1_MOUSE (1-114): 2.09e-14: 79.4: 18.32		FGF9_MOUSE (1-208): 2.53e-108: 310: 99.52
+	Hs
		181657 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		FGF10_HUMAN (47-194): 6.63e-72: 218: 41.89
+	Hs
		447013 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		FGF2_HUMAN (12-190): 2.92e-55: 179: 32.78
+	Mm
		549545 FGFR1_MOUSE (1-114): 2.09e-14: 79.4: 18.32		FGF2_MOUSE (14-190): 4.37e-56: 176: 32.02
+	Hs
		399128 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		FGF1_HUMAN (58-195): 8.47e-55: 173: 38.85
+	Hs
		441802 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		FGF4_HUMAN (28-191): 1.26e-53: 172: 38.55
+	Mm
		555272 FGFR1_MOUSE (1-114): 2.09e-14: 79.4: 18.32		FGF23_MOUSE (18-206): 1.65e-44: 150: 23.74
+	Hs
		320638 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		FGF19_HUMAN (42-206): 1.83e-44: 149: 25.14
+	Hs
		225915 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		FGF17_HUMAN (19-193): 6.04e-42: 142: 25.67
+	Mm
		555273 FGFR1_MOUSE (1-114): 2.09e-14: 79.4: 18.32		FGF21_MOUSE (49-191): 1.28e-37: 131: 30.52