HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	25065853
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0016310 - phosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 770
+	Hs
		776626 EPHA5_HUMAN (1-777): 0: 622: 20.18		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		384414 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		499238 KIT_HUMAN (19-794): 1.17e-165: 506: 24.62		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		384428 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		434150 RET_HUMAN (453-801): 9.71e-98: 330: 48.63		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		849879 EPHA4_HUMAN (1-781): 0: 622: 20.78		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		855286 EPHB4_HUMAN (1-786): 8.14e-179: 541: 17.79		STAT2_HUMAN (1-728): 0: 786: 38.47
+	Mm
		786524 TIE2_MOUSE (478-783): 1.05e-71: 257: 44.44		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		499250 KIT_HUMAN (19-794): 1.17e-165: 506: 24.62		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		499239 KIT_HUMAN (19-794): 1.17e-165: 506: 24.62		STA5A_HUMAN (1-734): 0: 745: 30.42
+	Hs
		384522 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		729621 VGFR2_HUMAN (5-342): 3.81e-17: 88.6: 16.58		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		507894 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		572592 VGFR1_HUMAN (40-357): 6.77e-13: 74.8: 13.25		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		601474 FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Mm
		729405 VGFR3_MOUSE (49-372): 2.85e-10: 66.3: 15.46		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		729622 VGFR2_HUMAN (5-342): 3.81e-17: 88.6: 16.58		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		572594 VGFR1_HUMAN (40-357): 6.77e-13: 74.8: 13.25		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Hs
		601481 FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56		STA5B_HUMAN (1-734): 0: 752: 30.55
+	Hs
		601477 FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56		STA5A_HUMAN (1-734): 0: 745: 30.42