HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: KS6A3 (P51812)
Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2)
Gene: RPS6KA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	18156174
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0001501 - skeletal system development GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 740
+	Hs
		384525 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		384892 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		434163 RET_HUMAN (453-801): 9.71e-98: 330: 48.63		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		665151 EPHA2_HUMAN (1-788): 0: 595: 21.50		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		568557 EPHA2_HUMAN (1-788): 0: 595: 21.50		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Hs
		507919 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		665243 EPHA2_HUMAN (1-788): 0: 595: 21.50		KS6A2_HUMAN (7-327): 3.91e-100: 326: 24.02
+	Hs
		601482 FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Hs
		607926 FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31		KS6A3_HUMAN (1-740): 0: 844: 100.00
+	Rn
		979772 FGFR1_RAT (1-114): 1.76e-14: 79.7: 18.32		KS6A1_RAT (1-740): 0: 785: 78.17
+	Hs
		508016 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		601517 FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		607975 FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31		KS6A1_HUMAN (1-740): 0: 783: 77.90
+	Hs
		608180 FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31		KS6A6_HUMAN (1-740): 0: 771: 76.54
+	Hs
		384267 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		KAPCB_HUMAN (409-714): 3.04e-116: 355: 29.15
+	Hs
		507876 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		607895 FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31		AKT1_HUMAN (327-739): 2.87e-125: 383: 21.02
+	Hs
		507838 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		KAPCA_HUMAN (409-714): 2.99e-117: 358: 28.84
+	Hs
		508015 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		KS6A2_HUMAN (7-327): 3.91e-100: 326: 24.02
+	Hs
		601516 FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56		KS6A2_HUMAN (7-327): 3.91e-100: 326: 24.02