HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: USH1G (Q495M9)
pre-mRNA splicing regulator USH1G (Scaffold protein containing ankyrin repeats and SAM domain) (Usher syndrome type-1G protein)
Gene: USH1G

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~I-set, PK_Tyr_Ser-Thr~SAM_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 461
+	Hs
		474791 FGFR3_HUMAN (10-806): 0: 819: 100.00		POTEI_HUMAN (3-391): 5.05e-53: 193: 16.13
+	Hs
		665581 EPHB2_HUMAN (1-788): 0: 624: 19.15		ANK2_HUMAN (3-410): 4.21e-61: 217: 12.97
+	Hs
		665591 EPHB2_HUMAN (1-788): 0: 624: 19.15		ANK3_HUMAN (3-402): 2.02e-60: 215: 12.90
+	Hs
		665439 EPHA3_HUMAN (1-786): 0: 641: 20.68		KDIS_HUMAN (2-239): 5.09e-43: 164: 16.40
+	Hs
		872504 EPHA5_HUMAN (1-777): 0: 622: 20.18		KDIS_HUMAN (2-239): 5.09e-43: 164: 16.40
+	Hs
		665360 EPHA2_HUMAN (1-788): 0: 595: 21.50		KDIS_HUMAN (2-239): 5.09e-43: 164: 16.40
+	Hs
		1021409 NTRK3_HUMAN (130-757): 4.66e-167: 506: 24.59		ANK3_HUMAN (3-402): 2.02e-60: 215: 12.90
+	Hs
		665635 EPHB2_HUMAN (1-788): 0: 624: 19.15		CSKI2_HUMAN (3-69): 5.09e-16: 83: 27.54
+	Hs
		665280 EPHA2_HUMAN (1-788): 0: 595: 21.50		MIB1_HUMAN (69-350): 2.9e-22: 102: 12.08
+	Hs
		1081644 NTRK3_HUMAN (130-757): 4.66e-167: 506: 24.59		KDIS_HUMAN (2-239): 5.09e-43: 164: 16.40
+	Hs
		384666 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		ANK2_HUMAN (3-410): 4.21e-61: 217: 12.97
+	Hs
		1083907 NTRK2_HUMAN (159-756): 1.53e-161: 491: 25.51		KDIS_HUMAN (2-239): 5.09e-43: 164: 16.40
+	Rn
		728451 NTRK1_RAT (158-757): 1.01e-158: 483: 26.09		KDIS_RAT (2-239): 3.39e-43: 165: 16.80
+	Hs
		385704 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		KDIS_HUMAN (2-239): 5.09e-43: 164: 16.40
+	Hs
		385487 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		TANC1_HUMAN (13-360): 7.9e-33: 134: 13.35
+	Hs
		257545 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		ANR17_HUMAN (2-452): 1.17e-28: 121: 13.42
+	Hs
		385120 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		MIB1_HUMAN (69-350): 2.9e-22: 102: 12.08
+	Hs
		434183 RET_HUMAN (453-801): 9.71e-98: 330: 48.63		ANK3_HUMAN (3-402): 2.02e-60: 215: 12.90
+	Hs
		166874 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		ANR28_HUMAN (2-86): 1.09e-12: 72.6: 23.08
+	Hs
		385170 NTRK1_HUMAN (158-756): 5.97e-146: 450: 27.02		ANR44_HUMAN (1-64): 5.24e-10: 63.7: 17.39