HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: KLOTB (Q86Z14)
Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)
Gene: KLB

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17623664
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Glyco_hydro_1~I-set
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0017134 - fibroblast growth factor binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 806 Hs			1 1044
+	Mm
		192164 FGFR3_MOUSE (1-806): 0: 793: 92.32		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Mm
		93854 E9QNJ9_MOUSE (1-806): 0: 764: 88.26		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Hs
		508088 FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32		KLOTB_HUMAN (1-1044): 0: 1400: 100.00
+	Hs
		601541 FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56		KLOTB_HUMAN (1-1044): 0: 1400: 100.00
+	Hs
		608033 FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31		KLOTB_HUMAN (1-1044): 0: 1400: 100.00
+	Mm
		555271 FGFR1_MOUSE (1-114): 2.09e-14: 79.4: 18.32		KLOTB_MOUSE (1-1044): 0: 1356: 78.76
+	Mm
		975159 FGFR4_MOUSE (1-130): 8.75e-12: 70.9: 18.62		KLOTB_MOUSE (1-1044): 0: 1356: 78.76
+	Mm
		192157 FGFR1_MOUSE (1-114): 2.09e-14: 79.4: 18.32		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Mm
		192163 FGFR4_MOUSE (1-130): 8.75e-12: 70.9: 18.62		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Mm
		192159 FGFR2_MOUSE (1-114): 2.5e-11: 69.3: 16.79		KLOT_MOUSE (55-1025): 0: 1168: 45.83
+	Ce
		1014307 EGL15_CAEEL (46-248): 2.23e-22: 105: 18.78		Q18758_CAEEL (521-963): 3.03e-156: 473: 24.44