HitPredict

Interactor 1: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Interactor 2: STAC (Q99469)
SH3 and cysteine-rich domain-containing protein (Src homology 3 and cysteine-rich domain-containing protein)
Gene: STAC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.80	0.594

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 806 Hs			1 402
+	Hs
		609289 FGFR3_HUMAN (10-806): 0: 819: 100.00		LASP1_HUMAN (101-342): 4.76e-36: 134: 13.10
+	Hs
		277004 FGFR3_HUMAN (10-806): 0: 819: 100.00		STAM2_HUMAN (121-398): 4.04e-28: 117: 19.53
+	Hs
		609244 FGFR3_HUMAN (10-806): 0: 819: 100.00		GRB2_HUMAN (284-345): 2.15e-22: 96.4: 41.27
+	Hs
		412036 EPHA3_HUMAN (1-786): 0: 641: 20.68		FYN_HUMAN (210-397): 7.08e-38: 145: 15.79
+	Mm
		763386 EPHA4_MOUSE (1-781): 0: 626: 20.78		FYN_MOUSE (210-397): 5.52e-38: 145: 15.79
+	Hs
		412104 EPHA5_HUMAN (1-777): 0: 622: 20.18		FYN_HUMAN (210-397): 7.08e-38: 145: 15.79
+	Hs
		412105 EPHA4_HUMAN (1-781): 0: 622: 20.78		FYN_HUMAN (210-397): 7.08e-38: 145: 15.79
+	Hs
		277011 EPHA3_HUMAN (1-786): 0: 641: 20.68		STAM2_HUMAN (121-398): 4.04e-28: 117: 19.53
+	Hs
		433265 EPHB2_HUMAN (1-788): 0: 624: 19.15		YES_HUMAN (183-397): 1.74e-33: 133: 15.21
+	Hs
		277067 EPHA7_HUMAN (1-782): 0: 626: 21.22		STAM2_HUMAN (121-398): 4.04e-28: 117: 19.53
+	Hs
		277036 EPHA5_HUMAN (1-777): 0: 622: 20.18		STAM2_HUMAN (121-398): 4.04e-28: 117: 19.53
+	Hs
		277037 EPHA4_HUMAN (1-781): 0: 622: 20.78		STAM2_HUMAN (121-398): 4.04e-28: 117: 19.53
+	Hs
		872610 EPHB1_HUMAN (1-787): 0: 642: 18.08		GRB2_HUMAN (284-345): 2.15e-22: 96.4: 41.27
+	Hs
		665389 EPHA3_HUMAN (1-786): 0: 641: 20.68		GRB2_HUMAN (284-345): 2.15e-22: 96.4: 41.27
+	Hs
		924590 EPHA7_HUMAN (1-782): 0: 626: 21.22		GRB2_HUMAN (284-345): 2.15e-22: 96.4: 41.27
+	Hs
		665574 EPHB2_HUMAN (1-788): 0: 624: 19.15		GRB2_HUMAN (284-345): 2.15e-22: 96.4: 41.27
+	Mm
		872621 EPHB2_MOUSE (1-788): 0: 624: 19.03		GRB2_MOUSE (285-345): 2.63e-22: 96: 41.94
+	Hs
		872422 EPHA5_HUMAN (1-777): 0: 622: 20.18		GRB2_HUMAN (284-345): 2.15e-22: 96.4: 41.27
+	Hs
		872630 EPHA4_HUMAN (1-781): 0: 622: 20.78		GRB2_HUMAN (284-345): 2.15e-22: 96.4: 41.27
+	Hs
		665608 EPHB2_HUMAN (1-788): 0: 624: 19.15		ITSN1_HUMAN (94-368): 3.17e-14: 76.7: 10.95