HitPredict

Interactor 1: RPB2 (A5PJW8)
DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (RNA-directed RNA polymerase II subunit RPB2) (EC 2.7.7.48)
Gene: POLR2B

Interactor 2: RPB1 (G3MZY8)
DNA-directed RNA polymerase II subunit RPB1 (EC 2.7.7.6) (3'-5' exoribonuclease) (EC 3.1.13.-) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)
Gene: POLR2A

Species: Bos taurus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.61 1.00 0.785

The method score is based on:

Property Details
Experiments 26789250, 16769904
Identification Methods cross-linking study, anti bait coimmunoprecipitation
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains RNA_pol_Rpb1_1~RNA_pol_Rpb2_1, RNA_pol_Rpb1_3~RNA_pol_Rpb2_1, RNA_pol_Rpb1_4~RNA_pol_Rpb2_1, RNA_pol_Rpb1_5~RNA_pol_Rpb2_1, RNA_pol_Rpb1_4~RNA_pol_Rpb2_3, RNA_pol_Rpb1_5~RNA_pol_Rpb2_3, RNA_pol_Rpb1_4~RNA_pol_Rpb2_4, RNA_pol_Rpb1_4~RNA_pol_Rpb2_5, RNA_pol_Rpb1_5~RNA_pol_Rpb2_5, RNA_pol_Rpb1_1~RNA_pol_Rpb2_6, RNA_pol_Rpb1_2~RNA_pol_Rpb2_6, RNA_pol_Rpb1_3~RNA_pol_Rpb2_6, RNA_pol_Rpb1_4~RNA_pol_Rpb2_6, RNA_pol_Rpb1_5~RNA_pol_Rpb2_6, RNA_pol_Rpb1_1~RNA_pol_Rpb2_7, RNA_pol_Rpb1_2~RNA_pol_Rpb2_7, RNA_pol_Rpb1_5~RNA_pol_Rpb2_7
Common GO terms GO:0001055 - RNA polymerase II activity
GO:0003899 - DNA-directed 5'-3' RNA polymerase activity
GO:0003968 - RNA-dependent RNA polymerase activity
GO:0005665 - RNA polymerase II, core complex
GO:0008270 - zinc ion binding
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1174
Bt

1 1970
+ Hs
+ Hs
+ Sp
+ Sc
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+ Pf
+ Sc
+ Hs
+ Hv
+ Dm
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+ At
+ At
+ Hv

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024