HitPredict

Interactor 1: ROA2 (P22626)
Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)
Gene: HNRNPA2B1

Interactor 2: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	29845934, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	La~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing and 1 others more... GO:1990904 - ribonucleoprotein complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 353 Hs			1 582
+	Hs
		162065 HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		1116442 MSI2H_HUMAN (1-341): 1.1e-55: 186: 27.57		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		1031352 PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		516541 PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95		LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00
+	Hs
		161934 HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		162035 HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45		PABP4_HUMAN (1-208): 8.15e-41: 158: 11.98
+	Hs
		161948 HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		516358 ROA2_HUMAN (1-353): 9.07e-61: 200: 100.00		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		403212 PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67		LA_HUMAN (24-365): 5.96e-44: 163: 18.83
+	Hs
		516495 PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		516339 PABP1_HUMAN (12-200): 2.75e-37: 143: 18.95		PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29
+	Hs
		1031407 PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67		LAR4B_HUMAN (2-216): 8.48e-36: 145: 17.02
+	Hs
		162075 HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		162059 HNRDL_HUMAN (12-292): 9.81e-66: 215: 33.45		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Hs
		474021 PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67		PAB4L_HUMAN (1-203): 9.24e-35: 136: 11.85
+	Hs
		609883 ROA2_HUMAN (1-353): 9.07e-61: 200: 100.00		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50
+	Mm
		665745 PABP1_MOUSE (12-200): 3.28e-37: 143: 18.95		TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94
+	Hs
		1031367 PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67		LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23
+	Hs
		1031344 PABP4_HUMAN (19-200): 1.59e-38: 146: 19.67		ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50