HitPredict

Interactor 1: CCNO (P22674)
Cyclin-O
Gene: CCNO

Interactor 2: CDN1A (P38936)
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21)
Gene: CDKN1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 23443559
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDI~Cyclin_N
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005730 - nucleolus GO:0009410 - response to xenobiotic stimulus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 350 Hs			1 164
+	Hs
		303835 CCNB2_HUMAN (14-345): 1.8e-102: 308: 21.37		CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00
+	Hs
		538489 CCNB1_HUMAN (2-346): 1.61e-100: 305: 19.39		CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00
+	Hs
		758186 CCNA1_HUMAN (73-345): 7.93e-97: 296: 25.36		CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00
+	Hs
		590139 CCNA2_HUMAN (2-345): 1.71e-96: 294: 23.92		CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00
+	Mm
		624384 CCNB1_MOUSE (2-346): 4.73e-100: 303: 21.56		CDN1A_MOUSE (1-164): 5.34e-65: 197: 76.83
+	Mm
		763418 CCNA1_MOUSE (16-345): 1.38e-94: 289: 22.09		CDN1A_MOUSE (1-164): 5.34e-65: 197: 76.83
+	Hs
		331630 CCNE2_HUMAN (4-289): 4.08e-86: 267: 22.15		CDN1A_HUMAN (1-164): 1.8e-69: 209: 100.00
+	Hs
		303836 CCNB2_HUMAN (14-345): 1.8e-102: 308: 21.37		CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46
+	Hs
		538492 CCNB1_HUMAN (2-346): 1.61e-100: 305: 19.39		CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46
+	Hs
		804103 CCNA1_HUMAN (73-345): 7.93e-97: 296: 25.36		CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46
+	Hs
		590142 CCNA2_HUMAN (2-345): 1.71e-96: 294: 23.92		CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46
+	Hs
		610200 CCNO_HUMAN (1-350): 2.69e-97: 293: 100.00		CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46
+	Xl
		1151481 Q6GME9_XENLA (27-345): 5.34e-93: 285: 23.01		Q91646_XENLA (14-161): 6.75e-45: 148: 25.47
+	Xl
		1146034 Q66J45_XENLA (27-346): 1.39e-92: 284: 24.62		Q91646_XENLA (14-161): 6.75e-45: 148: 25.47
+	Hs
		303838 CCNB2_HUMAN (14-345): 1.8e-102: 308: 21.37		CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91
+	Hs
		538496 CCNB1_HUMAN (2-346): 1.61e-100: 305: 19.39		CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91
+	Hs
		590146 CCNA2_HUMAN (2-345): 1.71e-96: 294: 23.92		CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91
+	Mm
		803837 CCNA2_MOUSE (2-345): 2.54e-91: 281: 24.43		CDN1B_MOUSE (7-156): 1.74e-39: 134: 27.27
+	Hs
		331632 CCNE2_HUMAN (4-289): 4.08e-86: 267: 22.15		CDN1B_HUMAN (7-156): 2.96e-42: 141: 25.46
+	Hs
		331633 CCNE2_HUMAN (4-289): 4.08e-86: 267: 22.15		CDN1C_HUMAN (8-134): 7.02e-34: 123: 27.91