HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 0.60 0.773

The method score is based on:

Property Details
Experiments 25814554, 25872741, 28514442, 7544353, 8647120, 9872323, 31980649, 8083187, 9461587, 9178909, 11964172, 9108392, 33961781, 18273061, 17971399, 20936779, 12839496, 20124286, 12941616, 9234717 and 52 others

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Identification Methods two hybrid, affinity chromatography technology, pull down, fluorescent resonance energy transfer, far western blotting, biochemical, experimental interaction detection, isothermal titration calorimetry, two hybrid array, anti tag coimmunoprecipitation and 5 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001784 - phosphotyrosine residue binding
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
and 2 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024