HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: EPS8 (Q12929)
Epidermal growth factor receptor kinase substrate 8
Gene: EPS8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	25814554, 27629044, unassigned1126
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030426 - growth cone
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 822
+	Mm
		610587 CBL_MOUSE (1-906): 0: 888: 91.59		EPS8_MOUSE (1-822): 0: 956: 89.05
+	Hs
		610289 CBL_HUMAN (1-906): 0: 917: 100.00		CRKL_HUMAN (487-662): 3.07e-33: 132: 20.79
+	Hs
		433254 CBL_HUMAN (1-906): 0: 917: 100.00		YES_HUMAN (448-612): 4.43e-29: 124: 16.00
+	Hs
		610368 CBL_HUMAN (1-906): 0: 917: 100.00		BTK_HUMAN (422-701): 8.99e-28: 121: 10.77
+	Hs
		412013 CBL_HUMAN (1-906): 0: 917: 100.00		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Hs
		610288 CBL_HUMAN (1-906): 0: 917: 100.00		CRK_HUMAN (487-661): 8.43e-28: 116: 18.75
+	Mm
		610565 CBL_MOUSE (1-906): 0: 888: 91.59		CRKL_MOUSE (487-662): 4.53e-32: 128: 19.10
+	Hs
		557607 CBL_HUMAN (1-906): 0: 917: 100.00		NCK1_HUMAN (536-621): 1.03e-18: 90.8: 30.23
+	Mm
		610554 CBL_MOUSE (1-906): 0: 888: 91.59		FYN_MOUSE (454-613): 1.99e-27: 119: 16.57
+	Mm
		610609 CBL_MOUSE (1-906): 0: 888: 91.59		CRK_MOUSE (487-661): 1.5e-27: 115: 18.75
+	Hs
		610373 CBL_HUMAN (1-906): 0: 917: 100.00		ITK_HUMAN (508-590): 3.83e-13: 75: 23.81
+	Gg
		982678 Q98TY6_CHICK (21-906): 0: 874: 82.80		CRK_CHICK (487-661): 2.35e-28: 118: 17.05
+	Hs
		208994 CBL_HUMAN (1-906): 0: 917: 100.00		NCK2_HUMAN (535-612): 1.02e-12: 72.7: 24.69
+	Mm
		610633 CBL_MOUSE (1-906): 0: 888: 91.59		NCK1_MOUSE (536-621): 1.43e-18: 90.4: 30.23
+	Rn
		88779 D3ZV15_RAT (1-883): 0: 833: 89.00		CRK_RAT (487-661): 1.12e-27: 116: 18.75
+	Hs
		433339 CBLB_HUMAN (23-901): 0: 793: 46.65		YES_HUMAN (448-612): 4.43e-29: 124: 16.00
+	Hs
		412170 CBLB_HUMAN (23-901): 0: 793: 46.65		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Mm
		82738 B9EKI5_MOUSE (23-901): 0: 799: 47.22		NCK1_MOUSE (536-621): 1.43e-18: 90.4: 30.23
+	Hs
		557678 CBLB_HUMAN (23-901): 0: 793: 46.65		NCK1_HUMAN (536-621): 1.03e-18: 90.8: 30.23
+	Hs
		209046 CBLB_HUMAN (23-901): 0: 793: 46.65		NCK2_HUMAN (535-612): 1.02e-12: 72.7: 24.69