HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29891719
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 671
+	Hs
		610281 CBL_HUMAN (1-906): 0: 917: 100.00		ABL2_HUMAN (11-456): 2.1e-112: 366: 23.56
+	Mm
		337618 CBL_MOUSE (1-906): 0: 888: 91.59		ABL1_MOUSE (11-483): 1.01e-116: 377: 24.49
+	Hs
		337348 CBL_HUMAN (1-906): 0: 917: 100.00		ABL1_HUMAN (11-472): 1.06e-102: 340: 24.32
+	Hs
		69201 CBL_HUMAN (1-906): 0: 917: 100.00		A9UF07_HUMAN (11-472): 1.42e-99: 336: 24.32
+	Hs
		337458 CBLB_HUMAN (23-901): 0: 793: 46.65		ABL1_HUMAN (11-472): 1.06e-102: 340: 24.32
+	Hs
		69208 CBLB_HUMAN (23-901): 0: 793: 46.65		A9UF07_HUMAN (11-472): 1.42e-99: 336: 24.32
+	Hs
		433577 CBL_HUMAN (1-906): 0: 917: 100.00		LYN_HUMAN (23-289): 6.17e-28: 120: 32.13
+	Hs
		411595 CBL_HUMAN (1-906): 0: 917: 100.00		LCK_HUMAN (23-289): 1.31e-27: 119: 31.87
+	Hs
		435537 CBL_HUMAN (1-906): 0: 917: 100.00		IGF1R_HUMAN (20-312): 1.02e-26: 118: 31.21
+	Hs
		610276 CBL_HUMAN (1-906): 0: 917: 100.00		CSK_HUMAN (10-285): 1.03e-27: 118: 30.74
+	Mm
		610555 CBL_MOUSE (1-906): 0: 888: 91.59		CSK_MOUSE (10-285): 2.8e-28: 120: 31.10
+	Mm
		610545 CBL_MOUSE (1-906): 0: 888: 91.59		LYN_MOUSE (22-289): 6.81e-27: 117: 31.30
+	Mm
		411917 CBL_MOUSE (1-906): 0: 888: 91.59		LCK_MOUSE (23-289): 1.22e-26: 116: 32.23
+	Mm
		435877 CBL_MOUSE (1-906): 0: 888: 91.59		HCK_MOUSE (22-289): 7.61e-26: 114: 33.09
+	Rn
		88775 D3ZV15_RAT (1-883): 0: 833: 89.00		LYN_RAT (22-289): 5.94e-27: 117: 31.00
+	Mm
		82734 B9EKI5_MOUSE (23-901): 0: 799: 47.22		LYN_MOUSE (22-289): 6.81e-27: 117: 31.30
+	Hs
		411703 CBLB_HUMAN (23-901): 0: 793: 46.65		LCK_HUMAN (23-289): 1.31e-27: 119: 31.87
+	Mm
		782847 CBLB_MOUSE (23-901): 0: 791: 45.98		CSK_MOUSE (10-285): 2.8e-28: 120: 31.10
+	Mm
		411924 CBLB_MOUSE (23-901): 0: 791: 45.98		LCK_MOUSE (23-289): 1.22e-26: 116: 32.23
+	Hs
		434075 CBLC_HUMAN (42-504): 0: 620: 42.07		LYN_HUMAN (23-289): 6.17e-28: 120: 32.13