HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: ARHG7 (Q14155)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (COOL-1) (PAK-interacting exchange factor beta) (p85)
Gene: ARHGEF7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.724

Property	Details
Experiments	12935897, 16407834, 22588125, 14505571, 23175185
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0007165 - signal transduction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 803
+	Hs
		1027604 CBLB_HUMAN (23-901): 0: 793: 46.65		ARHG7_HUMAN (1-803): 0: 654: 100.00
+	Hs
		610407 CBL_HUMAN (1-906): 0: 917: 100.00		ARHG6_HUMAN (1-802): 1.77e-161: 489: 51.48
+	Mm
		1112077 CBLB_MOUSE (23-901): 0: 791: 45.98		ARHG7_MOUSE (1-797): 0: 570: 91.09
+	Hs
		548639 CBL_HUMAN (1-906): 0: 917: 100.00		VAV_HUMAN (1-778): 3.84e-111: 360: 16.96
+	Hs
		610308 CBL_HUMAN (1-906): 0: 917: 100.00		VAV2_HUMAN (1-712): 4.73e-111: 360: 17.04
+	Hs
		548699 CBLB_HUMAN (23-901): 0: 793: 46.65		VAV_HUMAN (1-778): 3.84e-111: 360: 16.96
+	Hs
		855791 CBLB_HUMAN (23-901): 0: 793: 46.65		VAV2_HUMAN (1-712): 4.73e-111: 360: 17.04
+	Hs
		1027629 CBLB_HUMAN (23-901): 0: 793: 46.65		VAV3_HUMAN (1-731): 3.11e-110: 358: 16.73
+	Mm
		82736 B9EKI5_MOUSE (23-901): 0: 799: 47.22		VAV2_MOUSE (1-712): 1.26e-107: 351: 16.38
+	Hs
		610517 CBL_HUMAN (1-906): 0: 917: 100.00		ITSN2_HUMAN (41-259): 5.37e-11: 68.6: 18.55
+	Hs
		610415 CBL_HUMAN (1-906): 0: 917: 100.00		ITSN1_HUMAN (21-245): 9.17e-09: 61.3: 14.68
+	Mm
		610657 CBL_MOUSE (1-906): 0: 888: 91.59		ITSN2_MOUSE (41-272): 1.94e-14: 79.8: 23.08
+	Mm
		610656 CBL_MOUSE (1-906): 0: 888: 91.59		ITSN1_MOUSE (21-252): 1.33e-10: 67.4: 17.00
+	Mm
		1112081 CBLB_MOUSE (23-901): 0: 791: 45.98		ITSN2_MOUSE (41-272): 1.94e-14: 79.8: 23.08
+	Hs
		1027627 CBLB_HUMAN (23-901): 0: 793: 46.65		ITSN2_HUMAN (41-259): 5.37e-11: 68.6: 18.55
+	Hs
		1027606 CBLB_HUMAN (23-901): 0: 793: 46.65		ITSN1_HUMAN (21-245): 9.17e-09: 61.3: 14.68
+	Ce
		136804 UNC89_CAEEL (420-858): 3.69e-18: 92.7: 9.34		VAV_CAEEL (2-676): 1.52e-78: 275: 16.64
+	Hs
		203228 SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22		ITSN1_HUMAN (21-245): 9.17e-09: 61.3: 14.68
+	Hs
		257713 ANR17_HUMAN (410-903): 9.9e-09: 61.5: 11.51		ITSN2_HUMAN (41-259): 5.37e-11: 68.6: 18.55