HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: UBE2U (Q5VVX9)
Ubiquitin-conjugating enzyme E2 U (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme U) (Ubiquitin carrier protein U) (Ubiquitin-protein ligase U)
Gene: UBE2U

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	31120930
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Cbl_N~UQ_con, UBA~UQ_con, UQ_con~zf-C3HC4
Common GO terms	GO:0000209 - protein polyubiquitination
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 321
+	Hs
		610305 CBL_HUMAN (1-906): 0: 917: 100.00		UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00
+	Hs
		610333 CBL_HUMAN (1-906): 0: 917: 100.00		UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67
+	Hs
		610323 CBL_HUMAN (1-906): 0: 917: 100.00		UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00
+	Hs
		610481 CBL_HUMAN (1-906): 0: 917: 100.00		UB2E2_HUMAN (3-153): 5.78e-68: 212: 23.18
+	Hs
		610469 CBL_HUMAN (1-906): 0: 917: 100.00		UB2E3_HUMAN (3-153): 1.57e-67: 211: 24.50
+	Hs
		610307 CBL_HUMAN (1-906): 0: 917: 100.00		UB2E1_HUMAN (3-153): 1.32e-66: 209: 25.17
+	Hs
		919717 CBLB_HUMAN (23-901): 0: 793: 46.65		UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67
+	Mm
		895981 CBLB_MOUSE (23-901): 0: 791: 45.98		UB2D1_MOUSE (4-153): 1.02e-75: 230: 30.00
+	Mm
		1112075 CBLB_MOUSE (23-901): 0: 791: 45.98		UBE2C_MOUSE (9-155): 2.67e-20: 88.2: 31.29
+	Hs
		849487 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2D1_HUMAN (4-153): 1.02e-75: 230: 30.00
+	Hs
		919905 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2D2_HUMAN (4-153): 8.78e-76: 230: 34.67
+	Hs
		895953 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2D3_HUMAN (4-153): 1.55e-74: 227: 34.00