HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: TENS4 (Q8IZW8)
Tensin-4 (C-terminal tensin-like protein)
Gene: TNS4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	34817293, 23774213
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 715
+	Hs
		610371 CBL_HUMAN (1-906): 0: 917: 100.00		SOS1_HUMAN (26-311): 8.31e-22: 103: 14.15
+	Hs
		522778 CBL_HUMAN (1-906): 0: 917: 100.00		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		610509 CBL_HUMAN (1-906): 0: 917: 100.00		SLAP2_HUMAN (399-601): 2.94e-21: 95.9: 22.22
+	Mm
		610629 CBL_MOUSE (1-906): 0: 888: 91.59		SLAP2_MOUSE (441-569): 5.9e-30: 121: 24.82
+	Hs
		610386 CBL_HUMAN (1-906): 0: 917: 100.00		SLAP1_HUMAN (382-578): 2.29e-16: 82: 17.70
+	Mm
		403415 CBL_MOUSE (1-906): 0: 888: 91.59		SRC_MOUSE (287-582): 2.58e-22: 103: 14.89
+	Mm
		610600 CBL_MOUSE (1-906): 0: 888: 91.59		SLAP1_MOUSE (376-573): 4.31e-16: 81.2: 15.79
+	Hs
		522956 CBLB_HUMAN (23-901): 0: 793: 46.65		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		523198 CBLC_HUMAN (42-504): 0: 620: 42.07		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		554300 MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58		SOS1_HUMAN (26-311): 8.31e-22: 103: 14.15
+	Hs
		522749 MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		554259 MUC1_HUMAN (449-906): 3.82e-14: 79.2: 10.58		MUC1_HUMAN (165-615): 4.13e-17: 88.3: 9.03
+	Mm
		1351630 PCLO_MOUSE (419-837): 7.66e-10: 65.3: 9.24		PCLO_MOUSE (5-615): 2.47e-13: 76.3: 9.47
+	Dm
		113976 M9PB30_DROME (534-906): 1.67e-13: 77.3: 9.66		M9PB30_DROME (8-625): 2.4e-09: 63.2: 8.15