HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: VGFR1 (P35969)
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Embryonic receptor kinase 2) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase receptor FLT)
Gene: Flt1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	15001553, 17962812
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 1333
+	Rn
		88773 D3ZV15_RAT (1-877): 0: 852: 96.24		VGFR1_RAT (1-1333): 0: 1002: 92.15
+	Hs
		572586 CBL_HUMAN (1-913): 0: 894: 91.05		VGFR1_HUMAN (21-1332): 0: 959: 81.49
+	Dm
		112207 O46034_DROME (45-457): 0: 756: 70.29		M9MRE1_DROME (26-1254): 0: 740: 25.66
+	Mm
		404008 CBL_MOUSE (1-913): 0: 923: 100.00		PGFRB_MOUSE (1-370): 4.58e-23: 108: 11.68
+	Hs
		557035 CBL_HUMAN (1-913): 0: 894: 91.05		PGFRA_HUMAN (1-415): 4.52e-27: 121: 12.31
+	Hs
		610268 CBL_HUMAN (1-913): 0: 894: 91.05		FLT3_HUMAN (14-571): 7.83e-23: 108: 13.79
+	Mm
		452178 CBL_MOUSE (1-913): 0: 923: 100.00		CSF1R_MOUSE (2-243): 1.29e-12: 74.6: 11.90
+	Mm
		403532 CBL_MOUSE (1-913): 0: 923: 100.00		KIT_MOUSE (2-268): 2.79e-12: 73.9: 11.04
+	Hs
		607879 CBL_HUMAN (1-913): 0: 894: 91.05		FGFR4_HUMAN (544-798): 7e-21: 101: 15.39
+	Hs
		452353 CBL_HUMAN (1-913): 0: 894: 91.05		PGFRB_HUMAN (1-370): 1.35e-20: 100: 10.94
+	Hs
		610266 CBL_HUMAN (1-913): 0: 894: 91.05		VGFR2_HUMAN (1-121): 1.31e-16: 88.1: 12.21
+	Hs
		601457 CBL_HUMAN (1-913): 0: 894: 91.05		FGFR2_HUMAN (2-125): 6.13e-16: 85.4: 10.42
+	Hs
		426985 CBL_HUMAN (1-913): 0: 894: 91.05		CSF1R_HUMAN (467-855): 8.22e-16: 85: 13.12
+	Hs
		499234 CBL_HUMAN (1-913): 0: 894: 91.05		KIT_HUMAN (2-233): 5.36e-12: 72.7: 13.23
+	Hs
		607956 CBLB_HUMAN (23-908): 0: 799: 45.92		FGFR4_HUMAN (544-798): 7e-21: 101: 15.39
+	Hs
		452407 CBLB_HUMAN (23-908): 0: 799: 45.92		PGFRB_HUMAN (1-370): 1.35e-20: 100: 10.94
+	Hs
		499262 CBLB_HUMAN (23-908): 0: 799: 45.92		KIT_HUMAN (2-233): 5.36e-12: 72.7: 13.23
+	Hs
		608187 CBLC_HUMAN (41-502): 0: 629: 42.16		FGFR4_HUMAN (544-798): 7e-21: 101: 15.39
+	Hs
		508055 OBSCN_HUMAN (410-874): 1.93e-12: 73.8: 12.79		FGFR1_HUMAN (3-163): 1.24e-17: 90.8: 11.05
+	Ce
		136802 UNC89_CAEEL (418-812): 4.65e-15: 82.7: 9.81		UNC22_CAEEL (2-125): 8.11e-11: 69.2: 8.57