HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: PK3CA (P42337)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PI3-kinase subunit alpha) (PI3K-alpha) (PI3Kalpha) (PtdIns-3-kinase subunit alpha) (EC 2.7.1.137) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha) (PtdIns-3-kinase subunit p110-alpha) (p110alpha) (Phosphoinositide-3-kinase catalytic alpha polypeptide) (Serine/threonine protein kinase PIK3CA) (EC 2.7.11.1)
Gene: Pik3ca

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	27474268
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0014823 - response to activity GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 913 Mm			1 1068
+	Hs
		610279 CBL_HUMAN (1-913): 0: 894: 91.05		PK3CA_HUMAN (1-1068): 0: 1315: 98.69
+	Mm
		193567 CBL_MOUSE (1-913): 0: 923: 100.00		PK3CD_MOUSE (1-1065): 0: 1163: 39.72
+	Mm
		610624 CBL_MOUSE (1-913): 0: 923: 100.00		PK3CB_MOUSE (1-1065): 0: 1070: 38.57
+	Hs
		610280 CBL_HUMAN (1-913): 0: 894: 91.05		PK3CB_HUMAN (1-1065): 0: 1050: 39.40
+	Mm
		610648 CBL_MOUSE (1-913): 0: 923: 100.00		PK3CG_MOUSE (1-1062): 0: 923: 32.29
+	Hs
		128867 SNPC4_HUMAN (503-874): 7.25e-09: 61.9: 13.04		P3C2A_HUMAN (113-1064): 0: 740: 26.63