HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: KSYK (P48025)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase)
Gene: Syk

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20670954
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005829 - cytosol GO:0007166 - cell surface receptor signaling pathway GO:0019901 - protein kinase binding GO:0043303 - mast cell degranulation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 629
+	Mm
		610560 CBL_MOUSE (1-913): 0: 923: 100.00		ZAP70_MOUSE (5-629): 0: 567: 53.36
+	Hs
		69201 CBL_HUMAN (1-913): 0: 894: 91.05		A9UF07_HUMAN (161-626): 3.99e-120: 394: 30.64
+	Mm
		610584 CBL_MOUSE (1-913): 0: 923: 100.00		EGFR_MOUSE (371-626): 1.19e-55: 206: 41.70
+	Hs
		337933 CBL_HUMAN (1-913): 0: 894: 91.05		EGFR_HUMAN (371-613): 2.67e-56: 208: 43.50
+	Hs
		383609 CBL_HUMAN (1-913): 0: 894: 91.05		ERBB2_HUMAN (371-613): 9.63e-52: 194: 42.28
+	Mm
		610554 CBL_MOUSE (1-913): 0: 923: 100.00		FYN_MOUSE (1-130): 7.17e-43: 163: 23.91
+	Mm
		536206 CBL_MOUSE (1-913): 0: 923: 100.00		FGR_MOUSE (1-130): 4.21e-42: 161: 26.09
+	Mm
		411917 CBL_MOUSE (1-913): 0: 923: 100.00		LCK_MOUSE (1-114): 2.04e-40: 156: 30.33
+	Mm
		435877 CBL_MOUSE (1-913): 0: 923: 100.00		HCK_MOUSE (1-114): 2.14e-40: 156: 27.87
+	Mm
		403415 CBL_MOUSE (1-913): 0: 923: 100.00		SRC_MOUSE (1-130): 7.67e-37: 146: 26.81
+	Hs
		412013 CBL_HUMAN (1-913): 0: 894: 91.05		FYN_HUMAN (1-130): 7.17e-43: 163: 23.91
+	Hs
		454799 CBL_HUMAN (1-913): 0: 894: 91.05		FGR_HUMAN (1-130): 4.45e-42: 161: 25.36
+	Hs
		442780 CBL_HUMAN (1-913): 0: 894: 91.05		HCK_HUMAN (1-114): 5.64e-41: 158: 26.23
+	Hs
		411595 CBL_HUMAN (1-913): 0: 894: 91.05		LCK_HUMAN (1-114): 1.76e-40: 156: 29.51
+	Hs
		433254 CBL_HUMAN (1-913): 0: 894: 91.05		YES_HUMAN (1-130): 3.56e-40: 156: 25.36
+	Hs
		522778 CBL_HUMAN (1-913): 0: 894: 91.05		SRC_HUMAN (1-130): 7.76e-37: 146: 26.81
+	Mm
		610545 CBL_MOUSE (1-913): 0: 923: 100.00		LYN_MOUSE (14-114): 6.68e-18: 89.2: 33.02
+	Mm
		337618 CBL_MOUSE (1-913): 0: 923: 100.00		ABL1_MOUSE (3-112): 4.65e-12: 71.5: 27.43
+	Hs
		433577 CBL_HUMAN (1-913): 0: 894: 91.05		LYN_HUMAN (14-114): 6.99e-18: 88.9: 33.02
+	Hs
		337348 CBL_HUMAN (1-913): 0: 894: 91.05		ABL1_HUMAN (3-112): 4.58e-12: 71.5: 27.43