HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: 1433G (P61982)
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: Ywhag

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	27474268
Identification Methods	affinity chromatography technology
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0030971 - receptor tyrosine kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 247
+	Mm
		610571 CBL_MOUSE (1-913): 0: 923: 100.00		1433E_MOUSE (1-244): 2.02e-141: 398: 63.53
+	Mm
		610578 CBL_MOUSE (1-913): 0: 923: 100.00		1433F_MOUSE (1-246): 1.51e-136: 385: 86.99
+	Hs
		610330 CBL_HUMAN (1-913): 0: 894: 91.05		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		610327 CBL_HUMAN (1-913): 0: 894: 91.05		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		610365 CBL_HUMAN (1-913): 0: 894: 91.05		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Mm
		610575 CBL_MOUSE (1-913): 0: 923: 100.00		1433Z_MOUSE (2-245): 8.46e-109: 315: 74.59
+	Mm
		610638 CBL_MOUSE (1-913): 0: 923: 100.00		1433B_MOUSE (2-247): 8.57e-109: 315: 75.81
+	Mm
		610576 CBL_MOUSE (1-913): 0: 923: 100.00		1433T_MOUSE (2-245): 3e-105: 306: 70.73
+	Hs
		610254 CBL_HUMAN (1-913): 0: 894: 91.05		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		610341 CBL_HUMAN (1-913): 0: 894: 91.05		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		610234 CBL_HUMAN (1-913): 0: 894: 91.05		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		610255 CBL_HUMAN (1-913): 0: 894: 91.05		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Ce
		1093846 Q6ABG8_CAEEL (41-510): 0: 675: 47.63		14332_CAEEL (4-241): 5.03e-109: 315: 75.21
+	Ce
		1090465 Q19019_CAEEL (49-575): 0: 650: 41.89		14332_CAEEL (4-241): 5.03e-109: 315: 75.21
+	Hs
		297821 K0754_HUMAN (544-913): 1.34e-28: 126: 15.54		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		297815 K0754_HUMAN (544-913): 1.34e-28: 126: 15.54		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		297824 K0754_HUMAN (544-913): 1.34e-28: 126: 15.54		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		683290 ZO1_HUMAN (435-850): 6.77e-22: 104: 14.39		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		646827 ZO1_HUMAN (435-850): 6.77e-22: 104: 14.39		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		683987 ZO1_HUMAN (435-850): 6.77e-22: 104: 14.39		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16