HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: SRBS2 (Q3UTJ2)
Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2)
Gene: Sorbs2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20886612
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 1180
+	Hs
		298949 CBL_HUMAN (1-913): 0: 894: 91.05		SRBS2_HUMAN (101-1180): 1.64e-167: 527: 86.47
+	Mm
		610608 CBL_MOUSE (1-913): 0: 923: 100.00		SRBS1_MOUSE (2-1180): 5.82e-85: 304: 27.75
+	Hs
		548639 CBL_HUMAN (1-913): 0: 894: 91.05		VAV_HUMAN (438-1179): 4.9e-79: 280: 12.35
+	Hs
		610393 CBL_HUMAN (1-913): 0: 894: 91.05		SPTN1_HUMAN (461-1072): 2.69e-61: 233: 15.64
+	Mm
		434794 CBL_MOUSE (1-913): 0: 923: 100.00		SPTA1_MOUSE (461-1031): 6.26e-51: 200: 13.46
+	Hs
		610308 CBL_HUMAN (1-913): 0: 894: 91.05		VAV2_HUMAN (431-1179): 2.04e-56: 213: 11.98
+	Hs
		360616 CBL_HUMAN (1-913): 0: 894: 91.05		SPTA1_HUMAN (461-1004): 1.79e-48: 192: 13.83
+	Hs
		235473 CBL_HUMAN (1-913): 0: 894: 91.05		VINEX_HUMAN (723-1180): 4.09e-50: 191: 29.01
+	Mm
		610640 CBL_MOUSE (1-913): 0: 923: 100.00		GRAP_MOUSE (795-1001): 2.02e-36: 139: 20.00
+	Hs
		208994 CBL_HUMAN (1-913): 0: 894: 91.05		NCK2_HUMAN (911-1126): 1.9e-26: 114: 20.26
+	Mm
		610598 CBL_MOUSE (1-913): 0: 923: 100.00		GRB2_MOUSE (1124-1178): 3.95e-16: 80.6: 26.79
+	Mm
		610633 CBL_MOUSE (1-913): 0: 923: 100.00		NCK1_MOUSE (947-1108): 2.24e-14: 78.5: 19.89
+	Mm
		610656 CBL_MOUSE (1-913): 0: 923: 100.00		ITSN1_MOUSE (91-1029): 2.89e-13: 77.1: 9.52
+	Mm
		610630 CBL_MOUSE (1-913): 0: 923: 100.00		SH3K1_MOUSE (1022-1180): 3.22e-12: 72.8: 29.63
+	Mm
		610657 CBL_MOUSE (1-913): 0: 923: 100.00		ITSN2_MOUSE (1097-1180): 8.82e-12: 72.2: 24.42
+	Hs
		610415 CBL_HUMAN (1-913): 0: 894: 91.05		ITSN1_HUMAN (393-1029): 1.54e-14: 81: 10.94
+	Hs
		610338 CBL_HUMAN (1-913): 0: 894: 91.05		GRB2_HUMAN (1124-1178): 3.95e-16: 80.6: 26.79
+	Hs
		557607 CBL_HUMAN (1-913): 0: 894: 91.05		NCK1_HUMAN (947-1108): 3.29e-14: 77.8: 19.89
+	Hs
		610472 CBL_HUMAN (1-913): 0: 894: 91.05		SH3K1_HUMAN (1022-1180): 3.73e-12: 72.8: 30.25
+	Hs
		47590 CBL_HUMAN (1-913): 0: 894: 91.05		A0A8V8TNS8_HUMAN (999-1125): 3.52e-10: 65.7: 20.57