HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: SRBS1 (Q62417)
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)
Gene: Sorbs1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	12765336, 11997497, 9447983
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0016600 - flotillin complex GO:0019901 - protein kinase binding GO:0045121 - membrane raft
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 1290
+	Mm
		610595 CBL_MOUSE (1-913): 0: 923: 100.00		SRBS2_MOUSE (71-1288): 3.66e-142: 464: 28.18
+	Hs
		298949 CBL_HUMAN (1-913): 0: 894: 91.05		SRBS2_HUMAN (133-1288): 2.01e-124: 414: 25.94
+	Hs
		360616 CBL_HUMAN (1-913): 0: 894: 91.05		SPTA1_HUMAN (221-1133): 1.56e-88: 319: 15.01
+	Mm
		434794 CBL_MOUSE (1-913): 0: 923: 100.00		SPTA1_MOUSE (213-1133): 3.68e-79: 290: 13.16
+	Hs
		235473 CBL_HUMAN (1-913): 0: 894: 91.05		VINEX_HUMAN (812-1288): 3.2e-43: 170: 31.19
+	Mm
		610657 CBL_MOUSE (1-913): 0: 923: 100.00		ITSN2_MOUSE (612-1288): 8.44e-31: 134: 10.01
+	Hs
		548639 CBL_HUMAN (1-913): 0: 894: 91.05		VAV_HUMAN (557-1289): 1.58e-33: 142: 11.16
+	Mm
		610640 CBL_MOUSE (1-913): 0: 923: 100.00		GRAP_MOUSE (927-1106): 5.16e-26: 109: 19.34
+	Hs
		610308 CBL_HUMAN (1-913): 0: 894: 91.05		VAV2_HUMAN (1033-1287): 9.51e-29: 127: 14.01
+	Mm
		610633 CBL_MOUSE (1-913): 0: 923: 100.00		NCK1_MOUSE (985-1211): 3.33e-20: 96.1: 18.41
+	Mm
		610604 CBL_MOUSE (1-913): 0: 923: 100.00		PLCG1_MOUSE (1175-1288): 3.28e-15: 83.5: 23.68
+	Mm
		610598 CBL_MOUSE (1-913): 0: 923: 100.00		GRB2_MOUSE (1233-1286): 2.84e-15: 78.4: 32.73
+	Mm
		610656 CBL_MOUSE (1-913): 0: 923: 100.00		ITSN1_MOUSE (698-1288): 1.24e-10: 68.5: 10.86
+	Hs
		208994 CBL_HUMAN (1-913): 0: 894: 91.05		NCK2_HUMAN (973-1208): 5.89e-20: 95.7: 20.97
+	Mm
		610630 CBL_MOUSE (1-913): 0: 923: 100.00		SH3K1_MOUSE (1103-1232): 2.04e-09: 64.1: 17.27
+	Mm
		610651 CBL_MOUSE (1-913): 0: 923: 100.00		CD2AP_MOUSE (1129-1288): 5.15e-09: 62.8: 29.48
+	Hs
		580928 CBL_HUMAN (1-913): 0: 894: 91.05		PLCG1_HUMAN (1175-1288): 7.56e-15: 82: 22.81
+	Hs
		610338 CBL_HUMAN (1-913): 0: 894: 91.05		GRB2_HUMAN (1233-1286): 2.84e-15: 78.4: 32.73
+	Hs
		47590 CBL_HUMAN (1-913): 0: 894: 91.05		A0A8V8TNS8_HUMAN (1022-1109): 4.21e-13: 74.9: 27.10
+	Hs
		557607 CBL_HUMAN (1-913): 0: 894: 91.05		NCK1_HUMAN (1129-1285): 3.56e-09: 62.4: 31.48