HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: NCK1 (Q99M51)
SH2/SH3 adapter protein Nck1 (Cytoplasmic protein Nck1) (NCK adapter protein 1) (Nck-1)
Gene: NCK1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	7517397, 8635998
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0030971 - receptor tyrosine kinase binding GO:0046875 - ephrin receptor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 377
+	Hs
		208994 CBL_HUMAN (1-913): 0: 894: 91.05		NCK2_HUMAN (1-376): 7.37e-90: 277: 68.50
+	Mm
		610657 CBL_MOUSE (1-913): 0: 923: 100.00		ITSN2_MOUSE (3-287): 2.25e-27: 116: 15.17
+	Mm
		610595 CBL_MOUSE (1-913): 0: 923: 100.00		SRBS2_MOUSE (46-287): 1.69e-23: 104: 17.74
+	Mm
		610546 CBL_MOUSE (1-913): 0: 923: 100.00		P85A_MOUSE (241-376): 2.56e-22: 100: 19.57
+	Mm
		610554 CBL_MOUSE (1-913): 0: 923: 100.00		FYN_MOUSE (6-130): 3.25e-22: 99.8: 21.26
+	Mm
		536206 CBL_MOUSE (1-913): 0: 923: 100.00		FGR_MOUSE (6-183): 4.16e-22: 99.5: 14.84
+	Mm
		140057 CBL_MOUSE (1-913): 0: 923: 100.00		P85B_MOUSE (252-376): 7.76e-20: 93.3: 24.41
+	Mm
		403415 CBL_MOUSE (1-913): 0: 923: 100.00		SRC_MOUSE (6-130): 5.82e-19: 90.1: 21.26
+	Mm
		610656 CBL_MOUSE (1-913): 0: 923: 100.00		ITSN1_MOUSE (5-127): 9.02e-17: 84.3: 15.45
+	Mm
		610555 CBL_MOUSE (1-913): 0: 923: 100.00		CSK_MOUSE (4-143): 8.51e-17: 83.3: 14.38
+	Mm
		610598 CBL_MOUSE (1-913): 0: 923: 100.00		GRB2_MOUSE (3-58): 7.7e-17: 80.6: 28.57
+	Hs
		298949 CBL_HUMAN (1-913): 0: 894: 91.05		SRBS2_HUMAN (49-287): 4.41e-23: 103: 16.74
+	Hs
		433254 CBL_HUMAN (1-913): 0: 894: 91.05		YES_HUMAN (6-152): 2.64e-22: 100: 19.87
+	Hs
		412013 CBL_HUMAN (1-913): 0: 894: 91.05		FYN_HUMAN (6-130): 3.47e-22: 99.8: 21.26
+	Hs
		454799 CBL_HUMAN (1-913): 0: 894: 91.05		FGR_HUMAN (6-130): 3.16e-22: 99.8: 21.26
+	Mm
		610640 CBL_MOUSE (1-913): 0: 923: 100.00		GRAP_MOUSE (2-60): 2.91e-13: 70.1: 20.34
+	Hs
		442780 CBL_HUMAN (1-913): 0: 894: 91.05		HCK_HUMAN (2-130): 1.23e-21: 98.3: 22.31
+	Mm
		610630 CBL_MOUSE (1-913): 0: 923: 100.00		SH3K1_MOUSE (58-209): 2.45e-11: 67.4: 18.18
+	Hs
		129202 CBL_HUMAN (1-913): 0: 894: 91.05		P85B_HUMAN (252-376): 9.28e-20: 92.9: 24.41
+	Hs
		47590 CBL_HUMAN (1-913): 0: 894: 91.05		A0A8V8TNS8_HUMAN (58-209): 1e-10: 64.7: 18.18