HitPredict

Interactor 1: KAPCB (P22694)
cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)
Gene: PRKACB

Interactor 2: H90B4 (Q58FF6)
Putative heat shock protein HSP 90-beta 4
Gene: HSP90AB4P

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.712

Property	Details
Experiments	28514442, 33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 351 Hs			1 505
+	Hs
		437900 KAPCB_HUMAN (1-351): 1.47e-164: 464: 100.00		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		437870 KAPCA_HUMAN (1-351): 3.72e-164: 463: 92.88		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		437898 KAPCG_HUMAN (1-351): 5.62e-161: 456: 78.63		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		431538 KAPCB_HUMAN (1-351): 1.47e-164: 464: 100.00		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		70435 B2RB89_HUMAN (1-351): 1.47e-164: 464: 100.00		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431511 KAPCA_HUMAN (1-351): 3.72e-164: 463: 92.88		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431537 KAPCG_HUMAN (1-351): 5.62e-161: 456: 78.63		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		437928 AKT2_HUMAN (5-347): 1.05e-149: 432: 37.46		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		437907 KPCL_HUMAN (6-351): 1.63e-146: 430: 35.75		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Hs
		438633 AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57		HS90B_HUMAN (1-504): 0: 671: 69.93
+	Bt
		964601 AKT1_BOVIN (2-347): 2.7e-148: 428: 39.60		HS90B_BOVIN (1-504): 0: 670: 69.76
+	Hs
		431573 AKT2_HUMAN (5-347): 1.05e-149: 432: 37.46		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		431548 KPCL_HUMAN (6-351): 1.63e-146: 430: 35.75		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Hs
		432376 AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57		HS90A_HUMAN (1-504): 0: 655: 62.96
+	Mm
		432411 AKT1_MOUSE (2-347): 8.96e-148: 427: 39.32		HS90A_MOUSE (1-504): 0: 652: 61.81
+	Hs
		1123447 AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57		H90B4_HUMAN (1-505): 0: 644: 100.00
+	Hs
		538102 KAPCB_HUMAN (1-351): 1.47e-164: 464: 100.00		ENPL_HUMAN (1-504): 0: 597: 35.70
+	Hs
		538446 AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57		ENPL_HUMAN (1-504): 0: 597: 35.70
+	Hs
		1123464 AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57		H90B3_HUMAN (1-504): 3.09e-143: 426: 58.87
+	Hs
		1162538 AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57		Q6PK50_HUMAN (1-301): 1.17e-138: 405: 80.26