HitPredict

Interactor 1: TIN (P22711)
Muscle-specific homeobox protein tinman (Msh-2) (NK-4)
Gene: TIN

Interactor 2: UBX (P83949)
Homeotic protein ultrabithorax
Gene: UBX

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	25869471, 32170121, 30247122
Identification Methods	protein complementation assay, affinity chromatography technology, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0003677 - DNA binding GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 416 Dm			1 389
+	Dm
		185813 PAX6_DROME (108-392): 5.23e-34: 136: 14.92		UBX_DROME (1-389): 3.26e-124: 365: 100.00
+	Dm
		950059 Q9VFK4_DROME (206-371): 1.19e-33: 135: 30.77		UBX_DROME (1-389): 3.26e-124: 365: 100.00
+	Dm
		611150 TIN_DROME (1-396): 2.71e-83: 262: 100.00		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Dm
		447318 TIN_DROME (1-396): 2.71e-83: 262: 100.00		SCR_DROME (289-353): 5.65e-24: 104: 80.00
+	Hs
		620134 PAX7_HUMAN (86-416): 1.13e-48: 174: 17.91		MNX1_HUMAN (197-387): 6.03e-52: 179: 33.67
+	Hs
		641345 PAX6_HUMAN (115-399): 2.02e-37: 142: 14.61		MNX1_HUMAN (197-387): 6.03e-52: 179: 33.67
+	Dm
		415559 PRD_DROME (108-413): 1.27e-36: 143: 17.48		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Hs
		620236 PAX3_HUMAN (88-413): 2.05e-47: 170: 16.36		MEOX2_HUMAN (114-366): 8.49e-34: 129: 20.16
+	Mm
		623693 PAX3_MOUSE (88-413): 1.25e-47: 171: 16.36		MEOX1_MOUSE (149-378): 2.72e-32: 123: 18.93
+	Mm
		623694 PAX3_MOUSE (88-413): 1.25e-47: 171: 16.36		MEOX2_MOUSE (114-366): 8.16e-32: 123: 19.76
+	Dm
		185806 PAX6_DROME (108-392): 5.23e-34: 136: 14.92		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Dm
		668287 Q9VFK4_DROME (206-371): 1.19e-33: 135: 30.77		ABDA_DROME (260-376): 4.98e-42: 157: 59.32
+	Hs
		446864 HXA5_HUMAN (128-376): 1.21e-36: 136: 18.25		HXD4_HUMAN (144-389): 1.64e-36: 135: 26.02
+	Hs
		641327 PAX6_HUMAN (115-399): 2.02e-37: 142: 14.61		HXC8_HUMAN (146-363): 3.56e-32: 123: 31.65
+	Mm
		453073 PAX6_MOUSE (115-399): 2.02e-37: 142: 14.61		HXA9_MOUSE (124-359): 5.29e-31: 121: 23.41
+	Hs
		211800 MSX2_HUMAN (244-387): 2.64e-37: 138: 36.81		TLX3_HUMAN (118-388): 1.09e-31: 123: 17.34
+	Hs
		453048 HXA5_HUMAN (128-376): 1.21e-36: 136: 18.25		HXB7_HUMAN (139-364): 7.88e-33: 124: 31.86
+	Dm
		185797 PAX6_DROME (108-392): 5.23e-34: 136: 14.92		ANTP_DROME (161-375): 5.32e-31: 123: 32.56
+	Dm
		367210 PRD_DROME (108-413): 1.27e-36: 143: 17.48		FTZ_DROME (296-353): 9.77e-22: 97.8: 79.31
+	Ce
		106235 VAB3_CAEEL (118-401): 1.21e-38: 146: 13.74		PAL1_CAEEL (261-358): 4e-19: 88.2: 45.37