HitPredict

Interactor 1: NR4A1 (P22736)
Nuclear receptor subfamily 4immunitygroup A member 1 (Early response protein NAK1) (Nuclear hormone receptor NUR/77) (Nur77) (Orphan nuclear receptor HMR) (Orphan nuclear receptor TR3) (ST-59) (Testicular receptor 3)
Gene: NR4A1

Interactor 2: NCOR2 (Q9Y618)
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
Gene: NCOR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	11559707, 16002533
Identification Methods	two hybrid, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035259 - nuclear glucocorticoid receptor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 598 Hs			1 2514
+	Hs
		795610 NR4A2_HUMAN (1-598): 1.06e-112: 350: 51.05		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		1025275 NR1H3_HUMAN (178-591): 7.99e-114: 348: 29.29		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		992457 PPARA_HUMAN (212-595): 3.12e-111: 342: 23.62		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		500510 THB_HUMAN (236-594): 2.38e-110: 340: 27.32		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		818890 RXRG_HUMAN (128-596): 4.19e-110: 339: 27.12		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		587211 RXRA_HUMAN (120-594): 4e-109: 337: 26.36		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		874405 NR1H2_HUMAN (181-592): 8.61e-104: 323: 23.53		NCOR2_HUMAN (1-2514): 0: 908: 100.00
+	Hs
		261493 NR1H3_HUMAN (178-591): 7.99e-114: 348: 29.29		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261481 PPARA_HUMAN (212-595): 3.12e-111: 342: 23.62		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261383 THB_HUMAN (236-594): 2.38e-110: 340: 27.32		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261399 RXRA_HUMAN (120-594): 4e-109: 337: 26.36		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Xl
		574911 THBA_XENLA (249-594): 5.49e-113: 343: 28.27		NCOR1_XENLA (1-2514): 7.28e-122: 434: 32.87
+	Hs
		261450 NR1H2_HUMAN (181-592): 8.61e-104: 323: 23.53		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Hs
		261429 HNF4A_HUMAN (223-597): 2.07e-100: 314: 23.81		NCOR1_HUMAN (1-2514): 9.88e-128: 453: 34.38
+	Dm
		115933 ECR_DROME (215-591): 9.5e-112: 356: 26.88		M9PGZ8_DROME (113-505): 6.74e-62: 238: 36.96
+	Mm
		986635 NR4A2_MOUSE (1-598): 2.1e-112: 349: 51.53		RCOR1_MOUSE (378-704): 1.76e-42: 166: 22.35
+	Mm
		1142685 ERR2_MOUSE (184-594): 1.71e-102: 319: 27.05		RCOR1_MOUSE (378-704): 1.76e-42: 166: 22.35
+	Mm
		1206787 NR1H3_MOUSE (170-592): 8.37e-104: 322: 26.73		Q8BK32_MOUSE (1-280): 1.47e-40: 155: 49.66
+	Hs
		782638 HNF4A_HUMAN (223-597): 2.07e-100: 314: 23.81		CIC_HUMAN (7-2131): 8.47e-18: 93.5: 9.33
+	Hs
		782595 HNF4A_HUMAN (223-597): 2.07e-100: 314: 23.81		KMT2C_HUMAN (679-1264): 4.24e-16: 88: 11.93