HitPredict

Interactor 1: TRX2 (P22803)
Thioredoxin-2 (Thioredoxin II) (TR-II) (Thioredoxin-1)
Gene: TRX2

Interactor 2: TRXB1 (P29509)
Thioredoxin reductase 1 (TR) (TrxR) (EC 1.8.1.9) (Thioredoxin peroxidase 1) (TPx) (Thioredoxin-dependent peroxide reductase 1)
Gene: TRR1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.835

Property	Details
Experiments	23414292, 18719252, 16272220
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Pyr_redox_2~Thioredoxin
Common GO terms	GO:0005829 - cytosol GO:0045454 - cell redox homeostasis
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 104 Sc			1 319
+	Sc
		606193 TRX1_YEAST (1-103): 9.82e-38: 124: 78.64		TRXB1_YEAST (1-319): 2.14e-100: 299: 100.00
+	Sc
		630631 TRX3_YEAST (2-103): 7.69e-35: 117: 42.16		TRXB1_YEAST (1-319): 2.14e-100: 299: 100.00
+	Sc
		630638 TRX3_YEAST (2-103): 7.69e-35: 117: 42.16		TRXB2_YEAST (1-319): 3.32e-98: 294: 85.58
+	At
		186687 TRXY1_ARATH (4-104): 7.7e-33: 114: 29.13		TRXB3_ARATH (5-317): 1.86e-95: 294: 51.27
+	Ec
		465105 THIO_ECOLI (6-104): 9e-34: 114: 32.67		TRXB_ECOLI (2-318): 4.48e-82: 252: 48.92
+	Hs
		452589 THIO_HUMAN (1-104): 2.21e-36: 120: 48.57		DLDH_HUMAN (2-313): 1.35e-70: 229: 16.67
+	Hs
		452782 PDIA6_HUMAN (6-98): 2.01e-29: 110: 22.92		DLDH_HUMAN (2-313): 1.35e-70: 229: 16.67
+	Dm
		954892 THIO2_DROME (1-104): 6.96e-33: 111: 43.40		TRXR1_DROME (3-311): 6.24e-67: 221: 14.33
+	At
		1114791 TRXH3_ARATH (2-103): 2.84e-33: 113: 37.14		DLDH1_ARATH (3-314): 2.96e-62: 207: 17.97
+	Cj
		1011632 Q0PBZ0_CAMJE (12-104): 2.67e-17: 72.4: 39.36		Q0PBZ1_CAMJE (5-319): 5.88e-71: 224: 34.06
+	At
		1155146 TRXY1_ARATH (4-104): 7.7e-33: 114: 29.13		Q8W4M1_ARATH (223-317): 4.84e-41: 144: 51.58