HitPredict

Interactor 1: CNOT1 (A5YKK6)
CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1)
Gene: CNOT1

Interactor 2: TTP (P26651)
mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36)
Gene: ZFP36

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

The method score is based on:

Property	Details
Experiments	29395067, 23644599
Identification Methods	proximity labelling technology, pull down, x-ray crystallography, isothermal titration calorimetry
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening GO:0000932 - P-body GO:0003723 - RNA binding and 5 others more... GO:0005634 - nucleus GO:0005829 - cytosol GO:0030014 - CCR4-NOT complex GO:0060213 - positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:1900153 - positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	2376
Hs

1	326

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024