HitPredict

Interactor 1: ITA6 (P23229)
Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)]
Gene: ITGA6

Interactor 2: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	30024968, 32900848
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005178 - integrin binding GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 236
+	Hs
		613235 ITA6_HUMAN (1-1130): 0: 1347: 100.00		TSN5_HUMAN (7-235): 3.13e-55: 179: 21.67
+	Hs
		50294 ITA6_HUMAN (1-1130): 0: 1347: 100.00		TSN11_HUMAN (10-232): 1.83e-54: 177: 26.86
+	Hs
		613224 ITA6_HUMAN (1-1130): 0: 1347: 100.00		CD151_HUMAN (3-231): 1.89e-54: 176: 25.40
+	Hs
		602217 ITA6_HUMAN (1-1130): 0: 1347: 100.00		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		156132 ITA6_HUMAN (1-1130): 0: 1347: 100.00		TSN4_HUMAN (5-236): 2.15e-45: 153: 25.73
+	Hs
		326024 ITA6_HUMAN (1-1130): 0: 1347: 100.00		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		613274 ITA6_HUMAN (1-1130): 0: 1347: 100.00		TSN18_HUMAN (5-231): 2.35e-33: 122: 27.67
+	Hs
		50296 ITA7_HUMAN (3-1129): 0: 1183: 47.84		TSN11_HUMAN (10-232): 1.83e-54: 177: 26.86
+	Hs
		819448 ITA7_HUMAN (3-1129): 0: 1183: 47.84		CD151_HUMAN (3-231): 1.89e-54: 176: 25.40
+	Hs
		639879 ITA3_HUMAN (7-1108): 0: 936: 34.72		TSN5_HUMAN (7-235): 3.13e-55: 179: 21.67
+	Hs
		639875 ITA3_HUMAN (7-1108): 0: 936: 34.72		CD151_HUMAN (3-231): 1.89e-54: 176: 25.40
+	Hs
		602219 ITA3_HUMAN (7-1108): 0: 936: 34.72		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		639894 ITA3_HUMAN (7-1108): 0: 936: 34.72		TSN14_HUMAN (11-230): 6.42e-52: 170: 21.65
+	Mm
		192879 ITA3_MOUSE (9-1108): 0: 937: 35.02		CD151_MOUSE (4-231): 3e-47: 158: 25.91
+	Hs
		326269 ITA3_HUMAN (7-1108): 0: 936: 34.72		TSN12_HUMAN (1-226): 5.72e-46: 156: 22.54
+	Hs
		156133 ITA3_HUMAN (7-1108): 0: 936: 34.72		TSN4_HUMAN (5-236): 2.15e-45: 153: 25.73
+	Hs
		326026 ITA3_HUMAN (7-1108): 0: 936: 34.72		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		419182 ITAV_HUMAN (21-1083): 0: 880: 25.14		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		530541 ITA4_HUMAN (2-1096): 0: 865: 23.40		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		443039 ITA5_HUMAN (21-1086): 0: 855: 25.09		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59