HitPredict

Interactor 1: ITA6 (P23229)
Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; Processed integrin alpha-6 (Alpha6p)]
Gene: ITGA6

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007160 - cell-matrix adhesion GO:0010811 - positive regulation of cell-substrate adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1130 Hs			1 192
+	Hs
		564413 ITA6_HUMAN (1-1130): 0: 1347: 100.00		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		545210 ITA6_HUMAN (1-1130): 0: 1347: 100.00		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		613279 ITA6_HUMAN (1-1130): 0: 1347: 100.00		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		613231 ITA6_HUMAN (1-1130): 0: 1347: 100.00		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		613241 ITA6_HUMAN (1-1130): 0: 1347: 100.00		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		613232 ITA6_HUMAN (1-1130): 0: 1347: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		613234 ITA6_HUMAN (1-1130): 0: 1347: 100.00		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		436159 ITA6_HUMAN (1-1130): 0: 1347: 100.00		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Hs
		639881 ITA3_HUMAN (7-1108): 0: 936: 34.72		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		639878 ITA3_HUMAN (7-1108): 0: 936: 34.72		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		419189 ITAV_HUMAN (21-1083): 0: 880: 25.14		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		419150 ITAV_HUMAN (21-1083): 0: 880: 25.14		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		419149 ITAV_HUMAN (21-1083): 0: 880: 25.14		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		419236 ITAV_HUMAN (21-1083): 0: 880: 25.14		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		419184 ITAV_HUMAN (21-1083): 0: 880: 25.14		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		419191 ITAV_HUMAN (21-1083): 0: 880: 25.14		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		419185 ITAV_HUMAN (21-1083): 0: 880: 25.14		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		419186 ITAV_HUMAN (21-1083): 0: 880: 25.14		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		530400 ITA4_HUMAN (2-1096): 0: 865: 23.40		RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19
+	Hs
		419135 ITAV_HUMAN (21-1083): 0: 880: 25.14		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45