HitPredict

Interactor 1: SFPQ (P23246)
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)
Gene: SFPQ

Interactor 2: SFPQ (P23246)
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)
Gene: SFPQ

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.793

The method score is based on:

Property Details
Experiments 16169070, 37071682
Identification Methods two hybrid, cross-linking study, two hybrid pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains NOPS~NOPS, NOPS~RRM_1, RRM_1~RRM_1
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000380 - alternative mRNA splicing, via spliceosome
GO:0000724 - double-strand break repair via homologous recombination
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
and 24 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 707
Hs

1 707
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Last updated: 15 Jul 2024