HitPredict

Interactor 1: CNOT1 (A5YKK6)
CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1)
Gene: CNOT1

Interactor 2: CNOT9 (Q92600)
CCR4-NOT transcription complex subunit 9 (Cell differentiation protein RQCD1 homolog) (Rcd-1)
Gene: CNOT9

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.908

The method score is based on:

Property	Details
Experiments	24768540, 29395067, 26496610, 34887419
Identification Methods	pull down, proximity labelling technology, affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	DUF3819~Rcd1
Common GO terms	GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening GO:0000932 - P-body GO:0005634 - nucleus GO:0005829 - cytosol GO:0016020 - membrane and 5 others more... GO:0017148 - negative regulation of translation GO:0019904 - protein domain specific binding GO:0030014 - CCR4-NOT complex GO:0030015 - CCR4-NOT core complex GO:0033147 - negative regulation of intracellular estrogen receptor signaling pathway
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	2376
Hs

1	299

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024