Interactor 1: CNOT1 (A5YKK6)
CCR4-NOT transcription complex subunit 1 (CCR4-associated factor 1) (Negative regulator of transcription subunit 1 homolog) (NOT1H) (hNOT1)
Gene: CNOT1

Interactor 2: CNOT7 (Q9UIV1)
CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a)
Gene: CNOT7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.972

The method score is based on:

Property Details
Experiments 26186194, 28514442, 29395067, 33961781, 26496610, 34887419, 21278420, 22977175
Identification Methods affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, x-ray crystallography, pull down, molecular sieving
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CAF1~CNOT1_CAF1_bind
Common GO terms GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 - P-body
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005829 - cytosol
and 7 others

more...

Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 2376
Hs

1 285
+ Mm
+ Hs
+ Dm
+ Dm
+ Dm
+ Sp
+ Sc
+ Ce

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Last updated: 15 Jul 2024